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Affiliation
Department of Endocrinology and Diabetes, Adelaide and Meath Hospital, Tallaght, , Dublin 24, Ireland.Issue Date
2012-02-01T10:49:01ZMeSH
Acromegaly/therapyAdipose Tissue
*Athletes
Exercise
Female
Human Growth Hormone/*therapeutic use
Humans
Insulin-Like Growth Factor I/metabolism
Male
Muscles/drug effects
Oxygen/chemistry
Oxygen Consumption/drug effects
Recombinant Proteins/therapeutic use
*Sports
Time Factors
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Growth Horm IGF Res. 2009 Aug;19(4):308-19. Epub 2009 Jun 7.Journal
Growth hormone & IGF research : official journal of the Growth Hormone Research, Society and the International IGF Research SocietyDOI
10.1016/j.ghir.2009.04.023PubMed ID
19505835Abstract
The growth hormone (GH)/ insulin-like growth factor-I (IGF-I) axis exerts short-and long-term metabolic effects that are potentially important during exercise. Exercise is a potent stimulus to GH release and there is some evidence that the acute increase in GH is important in regulating substrate metabolism post-exercise. Regular exercise also increases 24-hour GH secretion rates, which potentially contributes to the physiologic changes induced by training. The effects of GH replacement in GH-deficient adults provide a useful model with which to study the effects of the more long-term effects of the GH/ IGF-I axis. There is convincing evidence that GH replacement increases exercise capacity. Measures of exercise performance including maximal oxygen uptake (VO2max) and ventilatory threshold (VeT) are impaired in GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delivery to exercising muscle, increased fatty acid availability with glycogen sparing, increased muscle strength, improved body composition and improved thermoregulation. Administration of supraphysiologic doses of GH to athletes increases fatty acid availability and reduces oxidative protein loss particularly during exercise, and increases lean body mass. It is not known whether these effects translate to improved athletic performance, although recombinant human GH is known to be widely abused in sport. The model of acromegaly provides evidence that long-term GH excess does not result in improved performance but it is possible that a "window" exists in which the protein anabolic effects of supraphysiologic GH might be advantageous.Language
engISSN
1532-2238 (Electronic)1096-6374 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1016/j.ghir.2009.04.023
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