Solar urticaria successfully treated with intravenous immunoglobulin.
Affiliation
Department of Dermatology, The Adelaide and Meath Hospital, Incorporating the, National Children's Hospital Tallaght, Dublin, Ireland.Issue Date
2012-02-01T10:48:51ZMeSH
AdultFemale
Humans
Immunoglobulins, Intravenous/*therapeutic use
Photosensitivity Disorders/*drug therapy/etiology
Sunlight/adverse effects
Treatment Outcome
Urticaria/*drug therapy/etiology
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Clin Exp Dermatol. 2009 Dec;34(8):e660-2. Epub 2009 Jun 22.Journal
Clinical and experimental dermatologyDOI
10.1111/j.1365-2230.2009.03374.xPubMed ID
19549230Abstract
Idiopathic solar urticaria (SU) is a rare, debilitating photodermatosis, which may be difficult to treat. First-line treatment with antihistamines is effective in mild cases, but remission after phototherapeutic induction of tolerance is often short-lived. Other treatment options include plasma exchange, photopheresis and cyclosporin. We present two cases of severe, idiopathic SU, which were resistant to conventional treatment. Both patients achieved remission after administration of intravenous immunoglobulin (IVIg) and have remained in remission at 13 months and 4 years, respectively. There are only two case reports of successful treatment of solar urticaria with IVIg. In our experience IVIg given at a total dose of 2 g/kg over several 5-day courses about a month apart is an effective treatment option for severe idiopathic SU. It is also generally safe, even if certainly subject to significant theoretical risks, such as induction of viral infection or anaphylaxis.Language
engISSN
1365-2230 (Electronic)0307-6938 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2230.2009.03374.x
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