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    Solar urticaria successfully treated with intravenous immunoglobulin.

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    Authors
    Hughes, R
    Cusack, C
    Murphy, G M
    Kirby, B
    Affiliation
    Department of Dermatology, The Adelaide and Meath Hospital, Incorporating the, National Children's Hospital Tallaght, Dublin, Ireland.
    Issue Date
    2012-02-01T10:48:51Z
    MeSH
    Adult
    Female
    Humans
    Immunoglobulins, Intravenous/*therapeutic use
    Photosensitivity Disorders/*drug therapy/etiology
    Sunlight/adverse effects
    Treatment Outcome
    Urticaria/*drug therapy/etiology
    
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    Citation
    Clin Exp Dermatol. 2009 Dec;34(8):e660-2. Epub 2009 Jun 22.
    Journal
    Clinical and experimental dermatology
    URI
    http://hdl.handle.net/10147/207875
    DOI
    10.1111/j.1365-2230.2009.03374.x
    PubMed ID
    19549230
    Abstract
    Idiopathic solar urticaria (SU) is a rare, debilitating photodermatosis, which may be difficult to treat. First-line treatment with antihistamines is effective in mild cases, but remission after phototherapeutic induction of tolerance is often short-lived. Other treatment options include plasma exchange, photopheresis and cyclosporin. We present two cases of severe, idiopathic SU, which were resistant to conventional treatment. Both patients achieved remission after administration of intravenous immunoglobulin (IVIg) and have remained in remission at 13 months and 4 years, respectively. There are only two case reports of successful treatment of solar urticaria with IVIg. In our experience IVIg given at a total dose of 2 g/kg over several 5-day courses about a month apart is an effective treatment option for severe idiopathic SU. It is also generally safe, even if certainly subject to significant theoretical risks, such as induction of viral infection or anaphylaxis.
    Language
    eng
    ISSN
    1365-2230 (Electronic)
    0307-6938 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2230.2009.03374.x
    Scopus Count
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    Tallaght University Hospital

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