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    Treatment of Helicobacter pylori infection 2010.

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    Authors
    O'Connor, Anthony
    Gisbert, Javier P
    McNamara, Deirdre
    O'Morain, Colm
    Affiliation
    Department of Gastroenterology, Adelaide and Meath Hospital incorporating the, National Children's Hospital/Trinity College Dublin, Tallaght, Dublin 24,, Ireland. oconna12@tcd.ie
    Issue Date
    2012-02-01T10:48:42Z
    MeSH
    Anti-Bacterial Agents/pharmacology/*therapeutic use
    Bismuth/therapeutic use
    *Drug Resistance, Bacterial
    Helicobacter Infections/*drug therapy
    Helicobacter pylori/*drug effects
    Humans
    Medication Adherence
    Treatment Outcome
    
    Metadata
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    Citation
    Helicobacter. 2010 Sep;15 Suppl 1:46-52. doi: 10.1111/j.1523-5378.2010.00774.x.
    Journal
    Helicobacter
    URI
    http://hdl.handle.net/10147/207869
    DOI
    10.1111/j.1523-5378.2010.00774.x
    PubMed ID
    21054653
    Abstract
    It is accepted that the success of Helicobacter pylori eradication treatment using standard triple therapy is declining. Resistance, particularly to clarithromycin, has been shown in numerous countries to be rising to a level where the use of standard triple therapy in its current form may no longer be justified. The two major factors influencing resistance are prior exposure to the antibiotic and compliance with therapy. Regimes based on bismuth and levofloxacin, which had previously been mainly second-line options, are now emerging as superior first-line options. Trials of sequential and concomitant therapies are also showing the usefulness of these treatments in different populations. Options for third and subsequent line therapies include furazolidone and rifabutin-based regimes. Susceptibility testing should be performed to maintain accurate data on resistance levels, and has also clinical utility in difficult to eradicate cases. None of these, however, will be successful unless compliance is improved upon. If compliance is assured and eradication confirmation pursued, it has been repeatedly illustrated that near full eradication is achievable.
    Language
    eng
    ISSN
    1523-5378 (Electronic)
    1083-4389 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1523-5378.2010.00774.x
    Scopus Count
    Collections
    Tallaght University Hospital

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