AffiliationAdelaide and Meath Hospital, Incorporating the National Children's Hospital,, Tallaght, Trinity College Dublin, Ireland. email@example.com
*Antacids/administration & dosage/adverse effects/therapeutic use
*Anti-Bacterial Agents/administration & dosage/adverse effects
Anti-Ulcer Agents/administration & dosage/adverse effects/therapeutic use
*Bismuth/administration & dosage/adverse effects/therapeutic use
*Capsules/administration & dosage/adverse effects/therapeutic use
Drug Administration Schedule
Drug Therapy, Combination
Helicobacter Infections/*drug therapy/microbiology
Helicobacter pylori/*drug effects
*Metronidazole/administration & dosage/adverse effects/therapeutic use
Omeprazole/administration & dosage/adverse effects/therapeutic use
Randomized Controlled Trials as Topic
*Tetracycline/administration & dosage/adverse effects/therapeutic use
MetadataShow full item record
CitationExpert Rev Anti Infect Ther. 2009 Sep;7(7):793-9.
JournalExpert review of anti-infective therapy
AbstractAn ideal antibiotic regimen for Helicobacter pylori should achieve eradication rates of approximately 90%. Current 7-day triple therapy is successful in about two-thirds of patients. A novel treatment is required to achieve higher eradication with minimal induction of bacterial resistance. The aim of this article is to evaluate the safety and efficacy of a single triple capsule (Pylera) containing bismuth, metronidazole and tetracycline, given with omeprazole for the eradication of H. pylori infection. Extensive literature searches were conducted using PubMed data from 1982 to 2007. This search included headings of H. pylori, bismuth and eradication therapy. The triple capsule Pylera, when given with omeprazole, achieved eradication rates ranging between 84 and 97%. Eradication rates were similar for clarithromycin- and metronidazole-resistant strains. Eradication rates with an omeprazole, bismuth, metronidazole and tetracycline regimen appeared comparable for metronidazole-resistant and -sensitive strains. This effect is not seen with the use of triple therapy in cases of clarithromycin resistance. Clinical trials did not report any serious side effects from bismuth-based regimens and compliance was similar to standard triple therapy. Bismuth-based triple therapy using Pylera is a simplified, effective and well-tolerated regimen achieving cure rates of above 90%.
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- Authors: Bago J, Halle ZB, Strinić D, Kućisec N, Jandrić D, Bevanda M, Tomić M, Bilić A
- Issue date: 2002 Jun 28
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