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    Establishing a family risk assessment clinic for breast cancer.

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    Authors
    Mulsow, Jurgen
    Lee, James
    Dempsey, Cathriona
    Rothwell, Jane
    Geraghty, James G
    Affiliation
    Tallaght Breast Unit, Adelaide and Meath Hospital Tallaght, Dublin, Ireland.
    Issue Date
    2012-02-01T10:48:14Z
    MeSH
    Adolescent
    Adult
    Breast Neoplasms/*genetics
    Female
    Genes, BRCA1
    Genes, BRCA2
    Genetic Testing
    Humans
    Middle Aged
    Mutation
    *Risk Assessment
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    Citation
    Breast J. 2009 Sep-Oct;15 Suppl 1:S33-8.
    Journal
    The breast journal
    URI
    http://hdl.handle.net/10147/207857
    DOI
    10.1111/j.1524-4741.2009.00825.x
    PubMed ID
    19775328
    Abstract
    Breast cancer is the most common cancer affecting European women and the leading cause of cancer-related death. A total of 15-20% of women who develop breast cancer have a family history and 5-10% a true genetic predisposition. The identification and screening of women at increased risk may allow early detection of breast cancer and improve prognosis. We established a family risk assessment clinic in May 2005 to assess and counsel women with a family history of breast cancer, to initiate surveillance, and to offer risk-reducing strategies for selected high-risk patients. Patients at medium or high risk of developing breast cancer according to NICE guidelines were accepted. Family history was determined by structured questionnaire and interview. Lifetime risk of developing breast cancer was calculated using Claus and Tyrer-Cuzick scoring. Risk of carrying a breast cancer-related gene mutation was calculated using the Manchester system. One thousand two hundred and forty-three patients have been referred. Ninety-two percent were at medium or high risk of developing breast cancer. Formal assessment of risk has been performed in 368 patients, 73% have a high lifetime risk of developing breast cancer, and 72% a Manchester score >or=16. BRCA1/2 mutations have been identified in 14 patients and breast cancer diagnosed in two. Our initial experience of family risk assessment has shown there to be a significant demand for this service. Identification of patients at increased risk of developing breast cancer allows us to provide individuals with accurate risk profiles, and enables patients to make informed choices regarding their follow-up and management.
    Language
    eng
    ISSN
    1524-4741 (Electronic)
    1075-122X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1524-4741.2009.00825.x
    Scopus Count
    Collections
    Tallaght University Hospital

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