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dc.contributor.authorHughes, David J
dc.contributor.authorMcManus, Ross
dc.contributor.authorNeary, Paul
dc.contributor.authorO'morain, Colm
dc.contributor.authorO'sullivan, Maria
dc.date.accessioned2012-02-01T10:48:08Z
dc.date.available2012-02-01T10:48:08Z
dc.date.issued2012-02-01T10:48:08Z
dc.identifier.citationEur J Gastroenterol Hepatol. 2011 Sep;23(9):807-12.en_GB
dc.identifier.issn1473-5687 (Electronic)en_GB
dc.identifier.issn0954-691X (Linking)en_GB
dc.identifier.pmid21818054en_GB
dc.identifier.doi10.1097/MEG.0b013e328349283een_GB
dc.identifier.urihttp://hdl.handle.net/10147/207854
dc.description.abstractOBJECTIVE: Vitamin D may protect against the development of inflammatory bowel disease (IBD). Several preliminary studies in separate geographical locations suggest that these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR). The data, however, are yet to be confirmed in large European cohorts. This study aimed to determine if common VDR polymorphisms affected IBD risk in an Irish population. MATERIALS AND METHODS: The study was based on a cohort of 1359 Irish participants. Frequencies of the common VDR gene polymorphisms rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case-control analysis of 660 patients with IBD and 699 controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between these variants and risk of IBD. RESULTS: There was no statistically significant effect observed on IBD risk for any of the four VDR polymorphisms tested. Furthermore, no significant differences were observed in susceptibility when the population was stratified by sex or IBD subtype (Crohn's disease or ulcerative colitis). Notably, however, there was an increased risk observed for both IBD and ulcerative colitis associated with heterozygote carriage of the FokI allele that approached significance (OR=1.21, 95% CI=0.95-1.53, P=0.12 and OR=1.36, 95% CI=0.98-1.89, P=0.06, respectively), this merits further investigation. CONCLUSION: This study indicates that there is no major effect for common variation in the VDR gene alone on predisposition to IBD in the Irish population.
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAllelesen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshColitis, Ulcerative/*geneticsen_GB
dc.subject.meshCrohn Disease/*geneticsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGenetic Predisposition to Diseaseen_GB
dc.subject.meshGenotypeen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIrelanden_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPolymorphism, Single Nucleotideen_GB
dc.subject.meshReceptors, Calcitriol/*geneticsen_GB
dc.titleCommon variation in the vitamin D receptor gene and risk of inflammatory bowel disease in an Irish case-control study.en_GB
dc.contributor.departmentDepartment of Clinical Medicine, Adelaide and Meath Hospital, Dublin, Ireland.en_GB
dc.identifier.journalEuropean journal of gastroenterology & hepatologyen_GB
dc.description.provinceLeinster
html.description.abstractOBJECTIVE: Vitamin D may protect against the development of inflammatory bowel disease (IBD). Several preliminary studies in separate geographical locations suggest that these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR). The data, however, are yet to be confirmed in large European cohorts. This study aimed to determine if common VDR polymorphisms affected IBD risk in an Irish population. MATERIALS AND METHODS: The study was based on a cohort of 1359 Irish participants. Frequencies of the common VDR gene polymorphisms rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case-control analysis of 660 patients with IBD and 699 controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between these variants and risk of IBD. RESULTS: There was no statistically significant effect observed on IBD risk for any of the four VDR polymorphisms tested. Furthermore, no significant differences were observed in susceptibility when the population was stratified by sex or IBD subtype (Crohn's disease or ulcerative colitis). Notably, however, there was an increased risk observed for both IBD and ulcerative colitis associated with heterozygote carriage of the FokI allele that approached significance (OR=1.21, 95% CI=0.95-1.53, P=0.12 and OR=1.36, 95% CI=0.98-1.89, P=0.06, respectively), this merits further investigation. CONCLUSION: This study indicates that there is no major effect for common variation in the VDR gene alone on predisposition to IBD in the Irish population.


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