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    Common variation in the vitamin D receptor gene and risk of inflammatory bowel disease in an Irish case-control study.

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    Authors
    Hughes, David J
    McManus, Ross
    Neary, Paul
    O'morain, Colm
    O'sullivan, Maria
    Affiliation
    Department of Clinical Medicine, Adelaide and Meath Hospital, Dublin, Ireland.
    Issue Date
    2012-02-01T10:48:08Z
    MeSH
    Adult
    Alleles
    Case-Control Studies
    Colitis, Ulcerative/*genetics
    Crohn Disease/*genetics
    Female
    Genetic Predisposition to Disease
    Genotype
    Humans
    Ireland
    Male
    Middle Aged
    Polymorphism, Single Nucleotide
    Receptors, Calcitriol/*genetics
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    Citation
    Eur J Gastroenterol Hepatol. 2011 Sep;23(9):807-12.
    Journal
    European journal of gastroenterology & hepatology
    URI
    http://hdl.handle.net/10147/207854
    DOI
    10.1097/MEG.0b013e328349283e
    PubMed ID
    21818054
    Abstract
    OBJECTIVE: Vitamin D may protect against the development of inflammatory bowel disease (IBD). Several preliminary studies in separate geographical locations suggest that these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR). The data, however, are yet to be confirmed in large European cohorts. This study aimed to determine if common VDR polymorphisms affected IBD risk in an Irish population. MATERIALS AND METHODS: The study was based on a cohort of 1359 Irish participants. Frequencies of the common VDR gene polymorphisms rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case-control analysis of 660 patients with IBD and 699 controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between these variants and risk of IBD. RESULTS: There was no statistically significant effect observed on IBD risk for any of the four VDR polymorphisms tested. Furthermore, no significant differences were observed in susceptibility when the population was stratified by sex or IBD subtype (Crohn's disease or ulcerative colitis). Notably, however, there was an increased risk observed for both IBD and ulcerative colitis associated with heterozygote carriage of the FokI allele that approached significance (OR=1.21, 95% CI=0.95-1.53, P=0.12 and OR=1.36, 95% CI=0.98-1.89, P=0.06, respectively), this merits further investigation. CONCLUSION: This study indicates that there is no major effect for common variation in the VDR gene alone on predisposition to IBD in the Irish population.
    Language
    eng
    ISSN
    1473-5687 (Electronic)
    0954-691X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1097/MEG.0b013e328349283e
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    Tallaght University Hospital

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