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    The impact of a revised EQ-5D population scoring on preference-based utility scores in an inflammatory arthritis cohort.

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    Authors
    Adams, Roisin
    Craig, Benjamin M
    Walsh, Cathal D
    Veale, Douglas J
    Bresnihan, Barry
    FitzGerald, Oliver
    Barry, Michael
    Affiliation
    National Centre for Pharmacoeconomics, St. James Hospital, Dublin, Ireland., radams@stjames.ie
    Issue Date
    2012-02-01T10:46:03Z
    MeSH
    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Arthritis, Psoriatic/economics/*physiopathology/psychology
    Arthritis, Rheumatoid/economics/*physiopathology/psychology
    Cohort Studies
    Cost-Benefit Analysis
    Female
    *Health Status
    Humans
    Male
    Middle Aged
    Models, Economic
    Quality of Life
    *Questionnaires
    Young Adult
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    Citation
    Value Health. 2011 Sep-Oct;14(6):921-7. Epub 2011 Jul 8.
    Journal
    Value in health : the journal of the International Society for Pharmacoeconomics , and Outcomes Research
    URI
    http://hdl.handle.net/10147/207835
    DOI
    10.1016/j.jval.2011.03.002
    PubMed ID
    21914514
    Abstract
    BACKGROUND AND OBJECTIVE: It is well established that there are problems with the EQ-5D. This is due to the original scoring methods used and how negative time trade-off (TTO) values were treated. A revised scoring method has been published. This article applies this to an inflammatory arthritis cohort. The objective is to examine the impact of a revised scoring system for the EQ-5D (UK) TTO on the utility estimates and in the case of rheumatoid arthritis, to explore the impact of using different utility metrics on the incremental cost-effectiveness ratio (ICER) results of an economic model. METHODS: A total of 504 patients with inflammatory arthritis were rescored using revised EQ-5D scoring, which uses an episodic random utility model to deal with negative TTO values. Differences in utility scores were compared and the new mapping coefficients were obtained. These were then used in an economic model to examine the impact on the ICER. RESULTS: In rheumatoid arthritis, the overall change is less for the revised EQ-5D scoring than with the original EQ-5D (TTO) but greater than the SF-6D: EQ-5D UK -0.22 (95% confidence interval [CI] -0.30 to -0.15), revised EQ-5D UK -0.16 (95% CI -0.21 to -0.10) and SF-6D -0.08 (95% CI -0.11 to -0.05). A similar trend is seen in the psoriatic arthritis group. The economic model produced different ICERs, when different utility measures were used; EQ-5D (TTO) euro42,402, SF-6D euro111,788, and revised EQ-5D (TTO) euro57,747. CONCLUSION: In the context of inflammatory arthritis, this article demonstrates that a revised scoring for EQ-5D may have a significant impact on utility estimates and on the output of the economic model.
    Language
    eng
    ISSN
    1524-4733 (Electronic)
    1098-3015 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jval.2011.03.002
    Scopus Count
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