Lack of differential pattern in central adiposity and metabolic syndrome in Barrett's esophagus and gastroesophageal reflux disease.
Affiliation
Department of Clinical Surgery, St. James' Hospital and Trinity College, Dublin, , Ireland.Issue Date
2012-02-01T10:45:48ZMeSH
Adenocarcinoma/etiologyBarrett Esophagus/*complications/pathology
Esophageal Neoplasms/etiology
Female
Gastroesophageal Reflux/*complications/pathology
Humans
Male
Metabolic Syndrome X/*complications/pathology
Metaplasia/etiology
Middle Aged
Obesity, Abdominal/*complications/metabolism/pathology
Metadata
Show full item recordCitation
Dis Esophagus. 2010 Jul;23(5):386-91. Epub 2010 Mar 26.Journal
Diseases of the esophagus : official journal of the International Society for, Diseases of the Esophagus / I.S.D.EDOI
10.1111/j.1442-2050.2010.01052.xPubMed ID
20353443Abstract
Obesity is an established risk factor for esophageal adenocarcinoma, although the mechanism is unclear. A pathway from reflux to inflammation through metaplasia is the dominant hypothesis, and an added role relating to visceral adiposity and the metabolic syndrome has been mooted in Barrett's esophagus (BE) patients. Whether BE differs from gastroesophageal reflux disease (GERD) in obesity and metabolic syndrome profiles is unclear, and this was the focus of this study. Patients with proven BE or GERD were randomly selected from the unit data registry and invited to attend for metabolic syndrome screening, anthropometry studies including segmental body composition analysis, and laboratory tests including fasting lipids, insulin, and C-reactive protein. Metabolic syndrome was defined using the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria. One hundred and eighteen BE patients and 113 age- and sex-matched GERD controls were studied. The incidence of obesity (body mass index >30 kg/m(2)) was 36% and 38%, respectively, with the pattern of fat deposition predominantly central and an estimated trunk fat mass of 13 and 14 kg, respectively. Using the NCEP criteria, metabolic syndrome was significantly more common in the BE cohort (30% vs 20%, P < 0.05), but there was no significant difference using IDF criteria (42% vs 37%, P= 0.340). Central obesity and the metabolic syndrome are common in both Barrett's and GERD cohorts, but not significantly different, suggesting that central obesity and the metabolic syndrome does not per se impact on the development of BE in a reflux population. In BE, the importance of obesity and the metabolic syndrome in disease progression merits further study.Language
engISSN
1442-2050 (Electronic)1120-8694 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1111/j.1442-2050.2010.01052.x
Scopus Count
Collections
Related articles
- Serum adiponectin, resistin, leptin concentration and central adiposity parameters in Barrett's esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD.
- Authors: Mokrowiecka A, Daniel P, Jasinska A, Pietruczuk M, Pawlowski M, Szczesniak P, Orszulak-Michalak D, Malecka-Panas E
- Issue date: 2012 Nov-Dec
- Hiatal hernia size, Barrett's length, and severity of acid reflux are all risk factors for esophageal adenocarcinoma.
- Authors: Avidan B, Sonnenberg A, Schnell TG, Chejfec G, Metz A, Sontag SJ
- Issue date: 2002 Aug
- Gastroesophageal reflux and Barrett's esophagus: a pathway to esophageal adenocarcinoma.
- Authors: Schlottmann F, Molena D, Patti MG
- Issue date: 2018 Sep
- Metabolic syndrome in relation to Barrett's esophagus and esophageal adenocarcinoma: Results from a large population-based case-control study in the Clinical Practice Research Datalink.
- Authors: Drahos J, Li L, Jick SS, Cook MB
- Issue date: 2016 Jun
- Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state.
- Authors: Ryan AM, Healy LA, Power DG, Byrne M, Murphy S, Byrne PJ, Kelleher D, Reynolds JV
- Issue date: 2008 Jun