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    Toll-like receptors as targets for immune disorders.

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    Authors
    Keogh, Brian
    Parker, Andrew E
    Affiliation
    Opsona Therapeutics Ltd., Institute of Molecular Medicine, Trinity Centre for, Health Sciences, St. James' Hospital, Dublin 8, Ireland. bkeogh@opsona.com
    Issue Date
    2012-02-01T10:45:08Z
    MeSH
    Animals
    Humans
    Immune System Diseases/*immunology/therapy
    Immunity, Innate/immunology
    Molecular Targeted Therapy
    Signal Transduction/immunology
    Toll-Like Receptors/*immunology/metabolism
    
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    Citation
    Trends Pharmacol Sci. 2011 Jul;32(7):435-42. Epub 2011 Apr 27.
    Journal
    Trends in pharmacological sciences
    URI
    http://hdl.handle.net/10147/207802
    DOI
    10.1016/j.tips.2011.03.008
    PubMed ID
    21529972
    Abstract
    Since the identification of the first Toll-like receptor (TLR) in humans in 1997, understanding of the molecular basis for innate immunity has increased significantly. The TLR family and downstream signalling pathways have been extensively characterised, There is now significant evidence suggesting a role for TLRs in human inflammatory and immune diseases such as rheumatoid arthritis, diabetes, allergy/asthma and atherosclerosis. Various approaches have been taken to identify novel therapeutic agents targeting TLRs including biologics, small molecules and nucleic acid-based drugs. Several are now being evaluated in the clinic and showing promise against various diseases. This review paper outlines the recent advances in the understanding of TLR biology and highlights novel TLR agonists and antagonists in development for the treatment of immune diseases.
    Language
    eng
    ISSN
    1873-3735 (Electronic)
    0165-6147 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.tips.2011.03.008
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