Copy-number variants in neurodevelopmental disorders: promises and challenges.
AffiliationDepartment of Psychiatry, Trinity Centre for Health Sciences, St. James Hospital,, Dublin, Ireland. firstname.lastname@example.org
*DNA Copy Number Variations
MetadataShow full item record
CitationTrends Genet. 2009 Dec;25(12):536-44. Epub 2009 Nov 10.
JournalTrends in genetics : TIG
AbstractCopy-number variation (CNV) is the most prevalent type of structural variation in the human genome. There is emerging evidence that copy-number variants (CNVs) provide a new vista on understanding susceptibility to neuropsychiatric disorders. Some challenges in the interpretation of current CNV studies include the use of overlapping samples, differing phenotypic definitions, an absence of population norms for CNVs and a lack of consensus in methods for CNV detection and analysis. Here, we review current CNV association study methods and results in autism spectrum disorders (ASD) and schizophrenia, and provide suggestions for design approaches to future studies that might maximize the translation of this work to etiological understanding.
- Detection and characterization of copy number variation in autism spectrum disorder.
- Authors: Marshall CR, Scherer SW
- Issue date: 2012
- Autism genetics: emerging data from genome-wide copy-number and single nucleotide polymorphism scans.
- Authors: Weiss LA
- Issue date: 2009 Nov
- The role of DNA copy number variation in schizophrenia.
- Authors: Tam GW, Redon R, Carter NP, Grant SG
- Issue date: 2009 Dec 1
- New technologies provide insights into genetic basis of psychiatric disorders and explain their co-morbidity.
- Authors: Rudan I
- Issue date: 2010 Jun
- Putatively benign copy number variants in subjects with idiopathic autism spectrum disorder and/or intellectual disability.
- Authors: Qiao Y, Harvard C, Riendeau N, Fawcett C, Liu X, Holden JJ, Lewis ME, Rajcan-Separovic E
- Issue date: 2008