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dc.contributor.authorBeddy, P
dc.contributor.authorHoward, J
dc.contributor.authorMcMahon, C
dc.contributor.authorKnox, M
dc.contributor.authorde Blacam, C
dc.contributor.authorRavi, N
dc.contributor.authorReynolds, J V
dc.contributor.authorKeogan, M T
dc.date.accessioned2012-02-01T10:45:03Z
dc.date.available2012-02-01T10:45:03Z
dc.date.issued2012-02-01T10:45:03Z
dc.identifier.citationBr J Surg. 2010 Jul;97(7):1028-34.en_GB
dc.identifier.issn1365-2168 (Electronic)en_GB
dc.identifier.issn0007-1323 (Linking)en_GB
dc.identifier.pmid20632268en_GB
dc.identifier.doi10.1002/bjs.7100en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207799
dc.description.abstractBACKGROUND: Obesity is associated with an increased incidence of oesophageal and oesophagogastric junction adenocarcinoma, in particular Siewert types I and II. This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with oesophageal squamous cell carcinoma and gastric adenocarcinoma, and in controls. METHOD: In total, 194 patients (110 with oesophageal/junctional adenocarcinoma, 38 with gastric adenocarcinoma and 46 with oesophageal squamous cell carcinoma) and 90 matched control subjects were recruited. The abdominal fat area was assessed using computed tomography (CT), and the total fat area (TFA), visceral fat area (VFA) and subcutaneous fat area (SFA) were calculated. RESULTS: Patients with oesophageal/junctional adenocarcinoma had significantly higher TFA and VFA values compared with controls (both P < 0.001), patients with gastric adenocarcinoma (P = 0.013 and P = 0.006 respectively) and patients with oesophageal squamous cell carcinoma (both P < 0.001). For junctional tumours, the highest TFA and VFA values were seen in patients with Siewert type I tumours (respectively P = 0.041 and P = 0.033 versus type III; P = 0.332 and P = 0.152 versus type II). CONCLUSION: Patients with oesophageal/junctional adenocarcinoma, in particular oesophageal and Siewert type I junctional tumours, have greater CT-defined visceral adiposity than patients with gastric adenocarcinoma or oesophageal squamous cell carcinoma, or controls.
dc.language.isoengen_GB
dc.subject.meshAdenocarcinoma/classification/*radiographyen_GB
dc.subject.meshAgeden_GB
dc.subject.meshCarcinoma, Squamous Cell/classification/*radiographyen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshCross-Sectional Studiesen_GB
dc.subject.meshEsophageal Neoplasms/classification/*radiographyen_GB
dc.subject.meshEsophagogastric Junction/*radiographyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIntra-Abdominal Fat/*radiographyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshObesity, Abdominal/*radiographyen_GB
dc.subject.meshSex Factorsen_GB
dc.subject.meshTomography, X-Ray Computeden_GB
dc.titleAssociation of visceral adiposity with oesophageal and junctional adenocarcinomas.en_GB
dc.contributor.departmentDepartment of Radiology, St James' Hospital and Trinity College Dublin, Dublin,, Ireland.en_GB
dc.identifier.journalThe British journal of surgeryen_GB
dc.description.provinceLeinster
html.description.abstractBACKGROUND: Obesity is associated with an increased incidence of oesophageal and oesophagogastric junction adenocarcinoma, in particular Siewert types I and II. This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with oesophageal squamous cell carcinoma and gastric adenocarcinoma, and in controls. METHOD: In total, 194 patients (110 with oesophageal/junctional adenocarcinoma, 38 with gastric adenocarcinoma and 46 with oesophageal squamous cell carcinoma) and 90 matched control subjects were recruited. The abdominal fat area was assessed using computed tomography (CT), and the total fat area (TFA), visceral fat area (VFA) and subcutaneous fat area (SFA) were calculated. RESULTS: Patients with oesophageal/junctional adenocarcinoma had significantly higher TFA and VFA values compared with controls (both P < 0.001), patients with gastric adenocarcinoma (P = 0.013 and P = 0.006 respectively) and patients with oesophageal squamous cell carcinoma (both P < 0.001). For junctional tumours, the highest TFA and VFA values were seen in patients with Siewert type I tumours (respectively P = 0.041 and P = 0.033 versus type III; P = 0.332 and P = 0.152 versus type II). CONCLUSION: Patients with oesophageal/junctional adenocarcinoma, in particular oesophageal and Siewert type I junctional tumours, have greater CT-defined visceral adiposity than patients with gastric adenocarcinoma or oesophageal squamous cell carcinoma, or controls.


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