• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. James's Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. James's Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4378
    UlsterS
    4378
    Connacht
    1408
    Munster
    62
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideHSE Library Guide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Elevated tumour marker: an indication for imaging?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    McMahon, Colm J
    Crowley, Vivion
    McCarroll, Nuala
    Dunne, Ruth
    Keogan, Mary T
    Affiliation
    Department of Diagnostic Imaging, St James Hospital, Dublin 8, Ireland., colmjmcmahon@yahoo.co.uk
    Issue Date
    2012-02-01T10:45:01Z
    MeSH
    Diagnostic Imaging/*statistics & numerical data
    Humans
    Neoplasms/blood/diagnosis
    Retrospective Studies
    Tumor Markers, Biological/*blood
    
    Metadata
    Show full item record
    Citation
    Ann Clin Biochem. 2010 Jul;47(Pt 4):327-30. Epub 2010 May 28.
    Journal
    Annals of clinical biochemistry
    URI
    http://hdl.handle.net/10147/207798
    DOI
    10.1258/acb.2010.009235
    PubMed ID
    20511377
    Abstract
    INTRODUCTION: The purpose of this study was to evaluate the utility of imaging examinations in patients with elevated tumour markers when (a) the tumour marker is not validated for as a primary diagnostic test; (b) the patient had no personal history of cancer and (c) the patient had no other imaging indication. MATERIALS AND METHODS: Patients without known cancer who had abnormal carcinoembryonic antigen, CA19-9, CA125 and/or CA15-3 serology over a one-year period were included. A retrospective medical record review was performed to assess the number of these cases who underwent imaging because of 'elevated tumour marker' in the absence of a clinical indication for imaging. The number and result of these imaging studies were evaluated. RESULTS: Eight hundred and nineteen patients were included. Of those, 25 patients (mean age: 67.8 [range 41-91] y), were imaged to evaluate: 'elevated tumour marker'. They underwent 29 imaging studies (mean [+/-standard deviation (SD)] per patient = 1.2 [+/-0.4]), and had 42 elevated tumour marker serology tests (mean [+/-SD] per patient = 1.7 [+/-0.7]). Four patients had >1 imaging test. No patient had an imaging study which diagnosed a malignancy or explained the elevated tumour marker. CONCLUSION: The non-judicious use of tumour markers can prompt further unnecessary investigations including imaging. In this study, there was no positive diagnostic yield for imaging performed for investigation of 'elevated tumour marker'. 'Elevated tumour marker', in the absence of a known underlying malignancy, should not be considered an independent indication for imaging.
    Language
    eng
    ISSN
    1758-1001 (Electronic)
    0004-5632 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1258/acb.2010.009235
    Scopus Count
    Collections
    St. James's Hospital

    entitlement

    Related articles

    • Does the assessment of serum markers in patients with lung cancer aid in the clinical decision making process?
    • Authors: Ebert W, Muley T, Drings P
    • Issue date: 1996 Jul-Aug
    • Tumour M2-pyruvate kinase: a gastrointestinal cancer marker.
    • Authors: Kumar Y, Tapuria N, Kirmani N, Davidson BR
    • Issue date: 2007 Mar
    • Tumour markers: their use and misuse by clinicians.
    • Authors: McGinley PJ, Kilpatrick ES
    • Issue date: 2003 Nov
    • A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases.
    • Authors: Kumar Y, Pinedo IR, Tapuria N, Zabron A, Davidson BR
    • Issue date: 2008 Oct
    • The clinical significance of elevated levels of serum CA 19-9.
    • Authors: Pavai S, Yap SF
    • Issue date: 2003 Dec
    HSE Library | Health Service Executive | Dr Steevens’ Hospital, Dublin 8 | Republic of Ireland | Eircode: D08 W2A8
    lenus@hse.ie
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.