Long-term health-related quality of life for disease-free esophageal cancer patients.
Affiliation
Department of Surgery, Trinity College Dublin/St James' Hospital, Trinity Centre , for Health Sciences, St James' Hospital, Dublin 8, Ireland.Issue Date
2012-02-01T10:44:56ZMeSH
AgedCohort Studies
Esophageal Neoplasms/*psychology/*surgery
Esophagectomy/*psychology
Female
Follow-Up Studies
Humans
Ireland
Male
Middle Aged
Postoperative Complications/psychology
Prospective Studies
Quality of Life/*psychology
Questionnaires
Survivors/*psychology
Metadata
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World J Surg. 2011 Aug;35(8):1853-60.Journal
World journal of surgeryDOI
10.1007/s00268-011-1123-6PubMed ID
21553202Abstract
BACKGROUND: Health-related quality of life (HRQL) has been studied extensively during the first year following esophagectomy, but little is known about HRQL in long-term survivors. The aim of this study was to investigate HRQL in patients alive at least 1 year after surgical resection for esophageal cancer using validated European Organisation for Research and Treatment of Cancer (EORTC) quality of life (QOL) questionnaires (QLQ). METHODS: Eligible patients, without known disease recurrence and at least 1 year after esophagectomy, were identified from a prospectively maintained database. Patients completed general (QLQ-C30) and esophageal cancer-specific (QLQ-OES18, OG25) questionnaires. A numeric score (0-100) was computed in each conceptual area and compared with validated cancer (n = 1031) and age-matched (n = 7802) healthy populations using two-tailed unpaired t-tests. A cohort of 80 patients had pretreatment scores recorded. RESULTS: Altogether, 132 of 156 eligible patients (84%) completed the self-rated questionnaire, 105 (67.3%) were men, and the mean age was 62 years (range 29-84 years). The mean time since esophagectomy was 70.3 months (12-299 months). Global health status was significantly reduced at least 1 year after esophagectomy (mean +/- SD score 48.4 +/- 18.6) when compared with patients with esophageal cancer prior to treatment (55.6 +/- 24.1) and the general population (71.2 +/- 22.4) (p < 0.0001). In a prospective cohort of eighty patients, symptoms related to swallowing difficulty, reflux, pain, and coughing significantly decreased in the long term (p < 0.0001). The degree of subjective swallowing dysfunction was highly correlated with a poor QOL (Spearman's rho = 0.508, p < 0.01). CONCLUSIONS: Global health status remains significantly reduced in long-term survivors after esophagectomy compared with population controls, and swallowing dysfunction is highly associated with this compromised QOL.Language
engISSN
1432-2323 (Electronic)0364-2313 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1007/s00268-011-1123-6
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