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    Long-term health-related quality of life for disease-free esophageal cancer patients.

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    Authors
    Donohoe, Claire L
    McGillycuddy, Erin
    Reynolds, John V
    Affiliation
    Department of Surgery, Trinity College Dublin/St James' Hospital, Trinity Centre , for Health Sciences, St James' Hospital, Dublin 8, Ireland.
    Issue Date
    2012-02-01T10:44:56Z
    MeSH
    Aged
    Cohort Studies
    Esophageal Neoplasms/*psychology/*surgery
    Esophagectomy/*psychology
    Female
    Follow-Up Studies
    Humans
    Ireland
    Male
    Middle Aged
    Postoperative Complications/psychology
    Prospective Studies
    Quality of Life/*psychology
    Questionnaires
    Survivors/*psychology
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    Citation
    World J Surg. 2011 Aug;35(8):1853-60.
    Journal
    World journal of surgery
    URI
    http://hdl.handle.net/10147/207795
    DOI
    10.1007/s00268-011-1123-6
    PubMed ID
    21553202
    Abstract
    BACKGROUND: Health-related quality of life (HRQL) has been studied extensively during the first year following esophagectomy, but little is known about HRQL in long-term survivors. The aim of this study was to investigate HRQL in patients alive at least 1 year after surgical resection for esophageal cancer using validated European Organisation for Research and Treatment of Cancer (EORTC) quality of life (QOL) questionnaires (QLQ). METHODS: Eligible patients, without known disease recurrence and at least 1 year after esophagectomy, were identified from a prospectively maintained database. Patients completed general (QLQ-C30) and esophageal cancer-specific (QLQ-OES18, OG25) questionnaires. A numeric score (0-100) was computed in each conceptual area and compared with validated cancer (n = 1031) and age-matched (n = 7802) healthy populations using two-tailed unpaired t-tests. A cohort of 80 patients had pretreatment scores recorded. RESULTS: Altogether, 132 of 156 eligible patients (84%) completed the self-rated questionnaire, 105 (67.3%) were men, and the mean age was 62 years (range 29-84 years). The mean time since esophagectomy was 70.3 months (12-299 months). Global health status was significantly reduced at least 1 year after esophagectomy (mean +/- SD score 48.4 +/- 18.6) when compared with patients with esophageal cancer prior to treatment (55.6 +/- 24.1) and the general population (71.2 +/- 22.4) (p < 0.0001). In a prospective cohort of eighty patients, symptoms related to swallowing difficulty, reflux, pain, and coughing significantly decreased in the long term (p < 0.0001). The degree of subjective swallowing dysfunction was highly correlated with a poor QOL (Spearman's rho = 0.508, p < 0.01). CONCLUSIONS: Global health status remains significantly reduced in long-term survivors after esophagectomy compared with population controls, and swallowing dysfunction is highly associated with this compromised QOL.
    Language
    eng
    ISSN
    1432-2323 (Electronic)
    0364-2313 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00268-011-1123-6
    Scopus Count
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    St. James's Hospital

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