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    A role for IGF-1R-targeted therapies in small-cell lung cancer?

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    Authors
    Gately, Kathy
    Collins, Ian
    Forde, Lydia
    Al-Alao, Bassel
    Young, Vincent
    Gerg, Michael
    Feuerhake, Friedrich
    O'Byrne, Kenneth
    Affiliation
    Department of Clinical Medicine, Trinity College Dublin, St. James Hospital,, Dublin 8, Ireland. kgately@stjames.ie
    Issue Date
    2012-02-01T10:44:49Z
    MeSH
    Aged
    Blotting, Western
    Female
    Humans
    Immunohistochemistry
    Kaplan-Meier Estimate
    Lung Neoplasms/*metabolism/mortality/pathology
    Male
    Middle Aged
    Prognosis
    Receptor, IGF Type 1/*biosynthesis
    Small Cell Lung Carcinoma/*metabolism/mortality/pathology
    Tumor Markers, Biological/*analysis
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    Citation
    Clin Lung Cancer. 2011 Jan;12(1):38-42.
    Journal
    Clinical lung cancer
    URI
    http://hdl.handle.net/10147/207791
    DOI
    10.3816/CLC.2011.n.005
    PubMed ID
    21273178
    Abstract
    BACKGROUND: Small-cell lung cancer (SCLC) is an aggressive disease with a poor prognosis. The insulin-like growth factor-1 receptor (IGF-1R) is an autocrine growth factor and an attractive therapeutic target in many solid tumors, but particularly in lung cancer. PATIENTS AND METHODS: This study examined tumor samples from 23 patients diagnosed with SCLC, 11 resected specimens and 12 nodal biopsies obtained by mediastinoscopy, for expression of IGF-1R using the monoclonal rabbit anti-IGF-1R (clone G11, Ventana Medical Systems, Tucson, AZ) and standard immunohistochemistry (IHC). RESULTS: All 23 tumor samples expressed IGF-1R with a range of stain intensity from weak (1+) to strong (3+). Ten tumors had a score of 3+, 7 tumors 2+, and 6 tumors 1+. Patient survival data were available for all 23 patients. Two patients died < 30 days post biopsy, therefore, the intensity of anti-IGF-1R immunostaining for 21 patients was correlated to survival. Patients with 3+ immunostaining had a poorer prognosis (P = .003). The overall survival of patients who underwent surgical resection was significantly better (median survival not reached) than patients who were not resected (median survival, 7.4 months) (P = .006). CONCLUSION: IGF-1R targeted therapies may have a role in the treatment of SCLC in combination with chemotherapy or as maintenance therapy. Further studies on the clinical benefit of targeting IGF-1R in SCLC are needed.
    Language
    eng
    ISSN
    1938-0690 (Electronic)
    1525-7304 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.3816/CLC.2011.n.005
    Scopus Count
    Collections
    St. James's Hospital

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