• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • St. James's Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • St. James's Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4378
    UlsterS
    4378
    Connacht
    1408
    Munster
    62
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideHSE Library Guide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Highly sensitivity adhesion molecules detection in hereditary haemochromatosis patients reveals altered expression.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Norris, S
    White, M
    Mankan, A K
    Lawless, M W
    Affiliation
    Hepatology Research Division and Department of Clinical Medicine, Institute of, Molecular Medicine, Trinity College Dublin, St. James Hospital, Dublin, Ireland.
    Issue Date
    2012-02-01T10:44:38Z
    MeSH
    Adult
    Aged
    Cell Adhesion Molecules/*blood
    E-Selectin/blood
    Female
    Flow Cytometry
    Gene Frequency
    Genotype
    Hemochromatosis/*blood/*genetics
    Histocompatibility Antigens Class I/*genetics
    Humans
    Intercellular Adhesion Molecule-1/blood
    Iron/metabolism
    L-Selectin/blood
    Male
    Membrane Proteins/*genetics
    Middle Aged
    Mutation
    P-Selectin/blood
    Vascular Cell Adhesion Molecule-1/blood
    Young Adult
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Int J Immunogenet. 2010 Apr;37(2):125-33. Epub 2010 Feb 19.
    Journal
    International journal of immunogenetics
    URI
    http://hdl.handle.net/10147/207785
    DOI
    10.1111/j.1744-313X.2010.00904.x
    PubMed ID
    20193033
    Abstract
    Several abnormalities in the immune status of patients with hereditary haemochromatosis (HH) have been reported, suggesting an imbalance in their immune function. This may include persistent production of, or exposure to, altered immune signalling contributing to the pathogenesis of this disorder. Adhesion molecules L-, E- and P-Selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) are some of the major regulators of the immune processes and altered levels of these proteins have been found in pathological states including cardiovascular diseases, arthritis and liver cancer. The aim of this study was to assess L-, E- and P-Selectin, ICAM-1 and VCAM-1 expression in patients with HH and correlate these results with HFE mutation status and iron indexes. A total of 139 subjects were diagnosed with HH (C282Y homozygotes = 87, C282Y/H63D = 26 heterozygotes, H63D homozygotes = 26), 27 healthy control subjects with no HFE mutation (N/N), 18 normal subjects heterozygous for the H63D mutation served as age-sex-matched controls. We observed a significant decrease in L-selectin (P = 0.0002) and increased E-selectin and ICAM-1 (P = 0.0006 and P = 0.0059) expression in HH patients compared with healthy controls. This study observes for the first time that an altered adhesion molecules profile occurs in patients with HH that is associated with specific HFE genetic component for iron overload, suggesting that differential expression of adhesion molecules may play a role in the pathogenesis of HH.
    Language
    eng
    ISSN
    1744-313X (Electronic)
    1744-3121 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1744-313X.2010.00904.x
    Scopus Count
    Collections
    St. James's Hospital

    entitlement

    Related articles

    • Elevated MCP-1 serum levels are associated with the H63D mutation and not the C282Y mutation in hereditary hemochromatosis.
    • Authors: Lawless MW, White M, Mankan AK, O'Dwyer MJ, Norris S
    • Issue date: 2007 Oct
    • [Molecular genetic diagnostics and screening of hereditary hemochromatosis].
    • Authors: Zlocha J, Kovács L, Pozgayová S, Kupcová V, Durínová S
    • Issue date: 2006 Jun
    • Hereditary hemochromatosis in a Brazilian university hospital in São Paulo State (1990-2000).
    • Authors: Martinelli AL, Filho R, Cruz S, Franco R, Tavella M, Secaf M, Ramalho L, Zucoloto S, Rodrigues S, Zago M
    • Issue date: 2005 Mar 31
    • Frequency of HFE H63D, S65C, and C282Y mutations in patients with iron overload and controls from Toledo, Spain.
    • Authors: de Diego C, Murga MJ, Martínez-Castro P
    • Issue date: 2004 Fall
    • HFE gene mutations analysis in Basque hereditary haemochromatosis patients and controls.
    • Authors: de Juan D, Reta A, Castiella A, Pozueta J, Prada A, Cuadrado E
    • Issue date: 2001 Dec
    HSE Library | Health Service Executive | Dr Steevens’ Hospital, Dublin 8 | Republic of Ireland | Eircode: D08 W2A8
    lenus@hse.ie
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.