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    Treatment of relapsing polychondritis in the era of biological agents.

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    Authors
    McCarthy, Eoghan M
    Cunnane, Gaye
    Affiliation
    Department of Rheumatology, St James' Hospital, Dublin 8, Ireland.
    Issue Date
    2012-02-01T10:44:33Z
    MeSH
    Antibodies, Monoclonal/*therapeutic use
    Antibodies, Monoclonal, Murine-Derived
    Antirheumatic Agents/therapeutic use
    Aortic Valve/drug effects/pathology/surgery
    Aortic Valve Insufficiency/*drug therapy/*immunology/surgery
    Azathioprine/therapeutic use
    C-Reactive Protein/metabolism
    Cardiac Surgical Procedures
    Collagen/immunology
    Hearing Loss, Sensorineural/etiology/surgery
    Humans
    Immunity, Cellular/drug effects/immunology
    Immunosuppressive Agents/*therapeutic use
    Lymphocyte Activation/drug effects/immunology
    Male
    Middle Aged
    Polychondritis, Relapsing/*complications/*drug therapy/physiopathology
    Treatment Outcome
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    Citation
    Rheumatol Int. 2010 Apr;30(6):827-8. Epub 2009 Dec 18.
    Journal
    Rheumatology international
    URI
    http://hdl.handle.net/10147/207782
    DOI
    10.1007/s00296-009-1308-6
    PubMed ID
    20020132
    Abstract
    Relapsing polychondritis (RP) is a rare disorder, often requiring high doses of immunosuppressive therapy to control its potentially life-threatening consequences. The advent of biological agents has added to the armamentarium available to treat RP, but the lack of controlled trials, along with the small numbers of patients and disease heterogeneity means that new therapies are prescribed without the benefits of rigorous clinical research. Thus, information on individual cases is of value in expanding our knowledge of the use of biologic agents in rare conditions. We report on the use of rituximab in a patient who subsequently developed catastrophic aortic incompetence, and we review the literature in relation to the use of this drug in RP.
    Language
    eng
    ISSN
    1437-160X (Electronic)
    0172-8172 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00296-009-1308-6
    Scopus Count
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    St. James's Hospital

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