Treatment of relapsing polychondritis in the era of biological agents.
Affiliation
Department of Rheumatology, St James' Hospital, Dublin 8, Ireland.Issue Date
2012-02-01T10:44:33ZMeSH
Antibodies, Monoclonal/*therapeutic useAntibodies, Monoclonal, Murine-Derived
Antirheumatic Agents/therapeutic use
Aortic Valve/drug effects/pathology/surgery
Aortic Valve Insufficiency/*drug therapy/*immunology/surgery
Azathioprine/therapeutic use
C-Reactive Protein/metabolism
Cardiac Surgical Procedures
Collagen/immunology
Hearing Loss, Sensorineural/etiology/surgery
Humans
Immunity, Cellular/drug effects/immunology
Immunosuppressive Agents/*therapeutic use
Lymphocyte Activation/drug effects/immunology
Male
Middle Aged
Polychondritis, Relapsing/*complications/*drug therapy/physiopathology
Treatment Outcome
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Show full item recordCitation
Rheumatol Int. 2010 Apr;30(6):827-8. Epub 2009 Dec 18.Journal
Rheumatology internationalDOI
10.1007/s00296-009-1308-6PubMed ID
20020132Abstract
Relapsing polychondritis (RP) is a rare disorder, often requiring high doses of immunosuppressive therapy to control its potentially life-threatening consequences. The advent of biological agents has added to the armamentarium available to treat RP, but the lack of controlled trials, along with the small numbers of patients and disease heterogeneity means that new therapies are prescribed without the benefits of rigorous clinical research. Thus, information on individual cases is of value in expanding our knowledge of the use of biologic agents in rare conditions. We report on the use of rituximab in a patient who subsequently developed catastrophic aortic incompetence, and we review the literature in relation to the use of this drug in RP.Language
engISSN
1437-160X (Electronic)0172-8172 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1007/s00296-009-1308-6
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