Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia.
AffiliationCancer Molecular Diagnostics, Central Pathology Laboratory, St. James Hospital,, Dublin, Ireland. email@example.com
Electrophoresis, Agar Gel
Leukemia, Myeloid, Acute/*genetics
fms-Like Tyrosine Kinase 3/*genetics
MetadataShow full item record
CitationIr J Med Sci. 2010 Dec;179(4):507-10. Epub 2010 Aug 31.
JournalIrish journal of medical science
AbstractBACKGROUND: Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells. Approximately half of all adult AML patients have a normal karyotype (NK-AML) and an intermediate risk prognosis. AIMS: To determine the incidence and prognostic significance of NPM1 and FLT3-ITD mutations in a population of patients with NK-AML. METHODS: FLT3-ITD and NPM1 mutation status was retrospectively sought in presentation samples from 44 NK-AML patients. RESULTS: FLT3-ITD and NPM1 mutations were detected in 45.5 and 54.5% of patients, respectively, allowing stratification according to genotype. CONCLUSIONS: FLT3-ITD and NPM1 mutation status can be defined in NK-AML. Prospective screening for these mutations is advocated in all NK-AML patients, as the genotype is of clinical importance when considering treatment options including stem cell transplantation.