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    Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia.

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    Authors
    Haslam, K
    Chadwick, N
    Kelly, J
    Browne, P
    Vandenberghe, E
    Flynn, C
    Conneally, E
    Langabeer, S E
    Affiliation
    Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James Hospital,, Dublin, Ireland. khaslam@stjames.ie
    Issue Date
    2012-02-01T10:44:24Z
    MeSH
    Adolescent
    Adult
    Aged
    Electrophoresis, Agar Gel
    Female
    Genotype
    Humans
    Leukemia, Myeloid, Acute/*genetics
    Male
    Middle Aged
    Mutation
    Nuclear Proteins/*genetics
    Phosphoproteins/*genetics
    Prognosis
    Retrospective Studies
    Seroepidemiologic Studies
    XYY Karyotype
    Young Adult
    fms-Like Tyrosine Kinase 3/*genetics
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    Citation
    Ir J Med Sci. 2010 Dec;179(4):507-10. Epub 2010 Aug 31.
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/207778
    DOI
    10.1007/s11845-010-0567-2
    PubMed ID
    20803351
    Abstract
    BACKGROUND: Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells. Approximately half of all adult AML patients have a normal karyotype (NK-AML) and an intermediate risk prognosis. AIMS: To determine the incidence and prognostic significance of NPM1 and FLT3-ITD mutations in a population of patients with NK-AML. METHODS: FLT3-ITD and NPM1 mutation status was retrospectively sought in presentation samples from 44 NK-AML patients. RESULTS: FLT3-ITD and NPM1 mutations were detected in 45.5 and 54.5% of patients, respectively, allowing stratification according to genotype. CONCLUSIONS: FLT3-ITD and NPM1 mutation status can be defined in NK-AML. Prospective screening for these mutations is advocated in all NK-AML patients, as the genotype is of clinical importance when considering treatment options including stem cell transplantation.
    Language
    eng
    ISSN
    1863-4362 (Electronic)
    0021-1265 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-010-0567-2
    Scopus Count
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    St. James's Hospital

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