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    Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure.

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    Authors
    Lee, Princeton Wen-Yuan
    Doyle, Aoife
    Stewart, Jeanette A
    Kristoffersen, Caroline J
    Stewart, William C
    Affiliation
    Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
    Issue Date
    2012-02-01T10:40:21Z
    MeSH
    Administration, Topical
    Adrenergic beta-Antagonists/*administration & dosage
    Blood Pressure/*drug effects/physiology
    Circadian Rhythm/*drug effects/physiology
    Glaucoma, Open-Angle/*drug therapy/physiopathology
    Humans
    Intraocular Pressure/*drug effects/physiology
    Ocular Hypertension/drug therapy/physiopathology
    Ophthalmic Solutions/administration & dosage
    Randomized Controlled Trials as Topic
    Timolol/*administration & dosage
    Tonometry, Ocular
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    Metadata
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    Citation
    Eur J Ophthalmol. 2010 Nov-Dec;20(6):1035-41.
    Journal
    European journal of ophthalmology
    URI
    http://hdl.handle.net/10147/207758
    PubMed ID
    20491052
    Abstract
    PURPOSE: To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. METHODS: This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been >/=2 weeks with >/=19 patients per treatment arm for a crossover, and >/=50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. RESULTS: For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p0.05). CONCLUSIONS: This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours.
    Language
    eng
    ISSN
    1724-6016 (Electronic)
    1120-6721 (Linking)
    Collections
    Royal Victoria Eye and Ear Hospital

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