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    Classification and treatment of radiation maculopathy.

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    Authors
    Horgan, Noel
    Shields, Carol L
    Mashayekhi, Arman
    Shields, Jerry A
    Affiliation
    Royal Victoria Eye and Ear Hospital, Dublin, Ireland. Noel.Horgan@rveeh.ie
    Issue Date
    2012-02-01T10:40:14Z
    MeSH
    Fluorescein Angiography
    Humans
    Radiation Injuries/*classification/etiology/*therapy
    Radiotherapy/*adverse effects
    Retina/*radiation effects
    Retinal Diseases/*classification/etiology/*therapy
    Tomography, Optical Coherence
    Uveal Neoplasms/radiotherapy
    
    Metadata
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    Citation
    Curr Opin Ophthalmol. 2010 May;21(3):233-8.
    Journal
    Current opinion in ophthalmology
    URI
    http://hdl.handle.net/10147/207754
    DOI
    10.1097/ICU.0b013e3283386687
    PubMed ID
    20393294
    Abstract
    PURPOSE OF REVIEW: Radiation maculopathy is a sight-limiting consequence of radiotherapy in the management of uveal melanoma and other intraocular tumors. In this review, we consider clinical, fluorescein angiographic and optical coherence tomographic findings, propose a classification for radiation maculopathy and discuss the management of this condition. RECENT FINDINGS: Radiation macular edema (RME) can be classified by optical coherence tomography into noncystoid or cystoid edema, with foveolar or extrafoveolar involvement. Optical coherence tomographic grading of RME has been found to correlate with visual acuity. Focal argon laser might have some limited benefit in the treatment of RME. Intravitreal triamcinolone and intravitreal antivascular endothelial growth factor agents can be of short-term benefit in the treatment of RME. In a randomized controlled trial, periocular triamcinolone significantly reduced rates of RME and vision loss up to 18 months following plaque radiotherapy for uveal melanoma. SUMMARY: Currently, there is no proven treatment for established RME, though periocular triamcinolone has been shown to have a preventive benefit. An accepted classification system for radiation maculopathy would be of benefit in planning and comparing future treatment trials.
    Language
    eng
    ISSN
    1531-7021 (Electronic)
    1040-8738 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1097/ICU.0b013e3283386687
    Scopus Count
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    Royal Victoria Eye and Ear Hospital

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