Reversal of prolonged rocuronium neuromuscular blockade with sugammadex in an obstetric patient with transverse myelitis.
AffiliationDepartment of Anaesthesiology, Rotunda Hospital, Dublin, Ireland., firstname.lastname@example.org
Androstanols/adverse effects/*antagonists & inhibitors
Neuromuscular Blockade/*adverse effects
Neuromuscular Nondepolarizing Agents/adverse effects/*antagonists & inhibitors
MetadataShow full item record
CitationInt J Obstet Anesth. 2010 Jul;19(3):333-6. Epub 2010 Jun 2.
JournalInternational journal of obstetric anesthesia
AbstractA 38-year-old wheelchair-bound primigravida with transverse myelitis presented at 38 weeks of gestation for elective caesarean section. Transverse myelitis, which is characterised by bilateral inflammation of the spinal cord and myelin destruction, is associated with myopathy, autonomic dysreflexia and pulmonary aspiration. Regional anaesthesia was contraindicated in this case as the patient had undergone two previous lumbar spinal fusion procedures. Rocuronium 1.2 mg/kg was used to facilitate rapid intubating conditions. The caesarean section proceeded uneventfully, but even after administration of neostigmine the patient exhibited prolonged neuromuscular blockade. After 3 h and 15 min sugammadex was obtained to reverse neuromuscular blockade; the drug was not stocked in our hospital. Sugammadex 4 mg/kg resulted in complete reversal of blockade after 2 min. We believe that myopathy associated with transverse myelitis led to the prolonged duration of action of rocuronium. Sugammadex is a relatively new drug with few reported side effects. In this case it was used to reverse neuromuscular blockade and prevented prolonged postoperative ventilatory support.
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