The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.
dc.contributor.author | Cooley, Sharon M | |
dc.contributor.author | Donnelly, Jennifer C | |
dc.contributor.author | Collins, Claire | |
dc.contributor.author | Geary, Michael P | |
dc.contributor.author | Rodeck, Charles H | |
dc.contributor.author | Hindmarsh, Peter C | |
dc.date.accessioned | 2012-02-01T10:38:08Z | |
dc.date.available | 2012-02-01T10:38:08Z | |
dc.date.issued | 2012-02-01T10:38:08Z | |
dc.identifier.citation | J Perinat Med. 2010 May;38(3):255-9. | en_GB |
dc.identifier.issn | 1619-3997 (Electronic) | en_GB |
dc.identifier.issn | 0300-5577 (Linking) | en_GB |
dc.identifier.pmid | 20121533 | en_GB |
dc.identifier.doi | 10.1515/JPM.2010.019 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10147/207726 | |
dc.description.abstract | AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks. | |
dc.language.iso | eng | en_GB |
dc.subject.mesh | Adult | en_GB |
dc.subject.mesh | Alcohol Drinking | en_GB |
dc.subject.mesh | Cohort Studies | en_GB |
dc.subject.mesh | Female | en_GB |
dc.subject.mesh | *Gestational Age | en_GB |
dc.subject.mesh | Humans | en_GB |
dc.subject.mesh | Insulin-Like Growth Factor Binding Protein 3/*blood | en_GB |
dc.subject.mesh | Insulin-Like Growth Factor I/*analysis | en_GB |
dc.subject.mesh | Insulin-Like Growth Factor II/*analysis | en_GB |
dc.subject.mesh | Pregnancy | en_GB |
dc.subject.mesh | Premature Birth/*blood | en_GB |
dc.subject.mesh | Prospective Studies | en_GB |
dc.subject.mesh | Smoking | en_GB |
dc.title | The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery. | en_GB |
dc.contributor.department | Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com | en_GB |
dc.identifier.journal | Journal of perinatal medicine | en_GB |
dc.description.province | Leinster | |
html.description.abstract | AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks. |