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dc.contributor.authorCooley, Sharon M
dc.contributor.authorDonnelly, Jennifer C
dc.contributor.authorCollins, Claire
dc.contributor.authorGeary, Michael P
dc.contributor.authorRodeck, Charles H
dc.contributor.authorHindmarsh, Peter C
dc.date.accessioned2012-02-01T10:38:08Z
dc.date.available2012-02-01T10:38:08Z
dc.date.issued2012-02-01T10:38:08Z
dc.identifier.citationJ Perinat Med. 2010 May;38(3):255-9.en_GB
dc.identifier.issn1619-3997 (Electronic)en_GB
dc.identifier.issn0300-5577 (Linking)en_GB
dc.identifier.pmid20121533en_GB
dc.identifier.doi10.1515/JPM.2010.019en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207726
dc.description.abstractAIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAlcohol Drinkingen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.mesh*Gestational Ageen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3/*blooden_GB
dc.subject.meshInsulin-Like Growth Factor I/*analysisen_GB
dc.subject.meshInsulin-Like Growth Factor II/*analysisen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPremature Birth/*blooden_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshSmokingen_GB
dc.titleThe relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.en_GB
dc.contributor.departmentRotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.comen_GB
dc.identifier.journalJournal of perinatal medicineen_GB
dc.description.provinceLeinster
html.description.abstractAIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.


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