The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.
Authors
Cooley, Sharon MDonnelly, Jennifer C
Collins, Claire
Geary, Michael P
Rodeck, Charles H
Hindmarsh, Peter C
Affiliation
Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.comIssue Date
2012-02-01T10:38:08ZMeSH
AdultAlcohol Drinking
Cohort Studies
Female
*Gestational Age
Humans
Insulin-Like Growth Factor Binding Protein 3/*blood
Insulin-Like Growth Factor I/*analysis
Insulin-Like Growth Factor II/*analysis
Pregnancy
Premature Birth/*blood
Prospective Studies
Smoking
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Show full item recordCitation
J Perinat Med. 2010 May;38(3):255-9.Journal
Journal of perinatal medicineDOI
10.1515/JPM.2010.019PubMed ID
20121533Abstract
AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.Language
engISSN
1619-3997 (Electronic)0300-5577 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1515/JPM.2010.019
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