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    The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.

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    Authors
    Cooley, Sharon M
    Donnelly, Jennifer C
    Collins, Claire
    Geary, Michael P
    Rodeck, Charles H
    Hindmarsh, Peter C
    Affiliation
    Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com
    Issue Date
    2012-02-01T10:38:08Z
    MeSH
    Adult
    Alcohol Drinking
    Cohort Studies
    Female
    *Gestational Age
    Humans
    Insulin-Like Growth Factor Binding Protein 3/*blood
    Insulin-Like Growth Factor I/*analysis
    Insulin-Like Growth Factor II/*analysis
    Pregnancy
    Premature Birth/*blood
    Prospective Studies
    Smoking
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    Metadata
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    Citation
    J Perinat Med. 2010 May;38(3):255-9.
    Journal
    Journal of perinatal medicine
    URI
    http://hdl.handle.net/10147/207726
    DOI
    10.1515/JPM.2010.019
    PubMed ID
    20121533
    Abstract
    AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
    Language
    eng
    ISSN
    1619-3997 (Electronic)
    0300-5577 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1515/JPM.2010.019
    Scopus Count
    Collections
    Rotunda Hospital

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