All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.
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Authors
Mocanu, EdgarShattock, Richard
Barton, David
Rogers, Melissa
Conroy, Ronan
Sheils, Orla
Collins, Claire
Martin, Cara
Harrison, Robert
O'Leary, John
Affiliation
Human Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of, Surgeons in Ireland, Dublin, Ireland. emocanu@rcsi.ieIssue Date
2012-02-01T10:38:03ZMeSH
Azoospermia/*diagnosis/*genetics/therapyCase-Control Studies
Cystic Fibrosis/diagnosis/*genetics
Cystic Fibrosis Transmembrane Conductance Regulator/*genetics
DNA Mutational Analysis
Gene Frequency
Genetic Testing/methods
Heterozygote Detection
Humans
Infertility, Male/etiology/genetics/therapy
Male
Mutation
Predictive Value of Tests
Prognosis
*Sperm Injections, Intracytoplasmic
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Fertil Steril. 2010 Nov;94(6):2448-50. Epub 2010 Apr 9.Journal
Fertility and sterilityDOI
10.1016/j.fertnstert.2010.02.029PubMed ID
20381036Abstract
We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.Language
engISSN
1556-5653 (Electronic)0015-0282 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1016/j.fertnstert.2010.02.029
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