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Affiliation
Department of Pathology and Laboratory Medicine, St Vincent's University, Hospital, Dublin 4, Ireland. Michael.J.Duffy@ucd.ieIssue Date
2012-02-01T10:35:06ZMeSH
AnimalsBreast Neoplasms/blood/*metabolism/pathology/surgery
Humans
Mucin-1/blood/chemistry/*metabolism
Neoplasm Metastasis
Postoperative Period
Preoperative Period
Tumor Markers, Biological/blood/chemistry/*metabolism
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Clin Chim Acta. 2010 Dec 14;411(23-24):1869-74. Epub 2010 Sep 8.Journal
Clinica chimica acta; international journal of clinical chemistryDOI
10.1016/j.cca.2010.08.039PubMed ID
20816948Abstract
CA 15-3 which detects soluble forms of MUC-1 protein is the most widely used serum marker in patients with breast cancer. Its main use is for monitoring therapy in patients with metastatic disease. In monitoring therapy in this setting, CA 15-3 should not be used alone but measured in conjunction with diagnostic imaging, clinical history and physical examination. CA 15-3 is particularly valuable for treatment monitoring in patients that have disease that cannot be evaluated using existing radiological procedures. CA 15-3 may also be used in the postoperative surveillance of asymptomatic women who have undergone surgery for invasive breast cancer. In this setting, serial determination can provide median lead-times of 5-6 months in the early detection of recurrent/metastatic breast cancer. It is unclear however, whether administering systemic therapy based on this lead-time improves patient outcome. Consequently, expert panels disagree on the utility of regularly measuring CA 15-3 in the postoperative surveillance of asymptomatic women following a diagnosis of breast cancer. The main limitation of CA 15-3 as a marker for breast cancer is that serum levels are rarely increased in patients with early or localized disease.Language
engISSN
1873-3492 (Electronic)0009-8981 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1016/j.cca.2010.08.039
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