Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation.
AffiliationRespiratory Sleep Disorders Unit, St. Vincent's University Hospital, Dublin,, Ireland.
Sleep Apnea, Obstructive/*physiopathology
MetadataShow full item record
CitationEur Respir J. 2009 May;33(5):1195-205.
JournalThe European respiratory journal : official journal of the European Society for, Clinical Respiratory Physiology
AbstractThere is increasing evidence that intermittent hypoxia plays a role in the development of cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of inflammatory pathways. The development of translational models of intermittent hypoxia has allowed investigation of its role in the activation of inflammatory mechanisms and promotion of cardiovascular disease in OSAS. There are noticeable differences in the response to intermittent hypoxia between body tissues but the hypoxia-sensitive transcription factors hypoxia-inducible factor-1 and nuclear factor-kappaB appear to play a key role in mediating the inflammatory and cardiovascular consequences of OSAS. Expanding our understanding of these pathways, the cross-talk between them and the activation of inflammatory mechanisms by intermittent hypoxia in OSAS will provide new avenues of therapeutic opportunity for the disease.
- Intermittent hypoxia and activation of inflammatory molecular pathways in OSAS.
- Authors: Ryan S, McNicholas WT
- Issue date: 2008 Oct
- Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome.
- Authors: Ryan S, Taylor CT, McNicholas WT
- Issue date: 2005 Oct 25
- Effect of chronic continual- and intermittent hypoxia-induced systemic inflammation on the cardiovascular system in rats.
- Authors: Xu XM, Yao D, Cai XD, Ding C, Lin QD, Wang LX, Huang XY
- Issue date: 2015 May
- [Mechanisms of cardiovascular damage in obstructive sleep apnea].
- Authors: Torre-Bouscoulet L, Castorena-Maldonado A, Sada-Ovalle I, Meza-Vargas MS
- Issue date: 2008 Nov-Dec
- Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS).
- Authors: Quercioli A, Mach F, Montecucco F
- Issue date: 2010 Sep