Chronic mitral regurgitation detected on cardiac MDCT: differentiation between functional and valvular aetiologies.
AffiliationDepartment of Radiology, St. Vincent's University Hospital, Dublin, Ireland.
Aged, 80 and over
Mitral Valve Insufficiency/classification/*etiology/*radiography/ultrasonography
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed/*methods
Ventricular Dysfunction, Left/*complications/*radiography/ultrasonography
MetadataShow full item record
CitationEur Radiol. 2010 Aug;20(8):1886-95. Epub 2010 Mar 23.
AbstractOBJECTIVE: To determine whether cardiac computed tomography (MDCT) can differentiate between functional and valvular aetiologies of chronic mitral regurgitation (MR) compared with echocardiography (TTE). METHODS: Twenty-seven patients with functional or valvular MR diagnosed by TTE and 19 controls prospectively underwent cardiac MDCT. The morphological appearance of the mitral valve (MV) leaflets, MV geometry, MV leaflet angle, left ventricular (LV) sphericity and global/regional wall motion were analysed. The coronary arteries were evaluated for obstructive atherosclerosis. RESULTS: All control and MR cases were correctly identified by MDCT. Significant differences were detected between valvular and control groups for anterior leaflet length (30 +/- 7 mm vs. 22 +/- 4 mm, P < 0.02) and thickness (3.0 +/- 1 mm vs. 2.2 +/- 1 mm, P < 0.01). High-grade coronary stenosis was detected in all patients with functional MR compared with no controls (P < 0.001). Significant differences in those with/without MV prolapse were detected in MV tent area (-1.0 +/- 0.6 mm vs. 1.3 +/- 0.9 mm, P < 0.0001) and MV tent height (-0.7 +/- 0.3 mm vs. 0.8 +/- 0.8 mm, P < 0.0001). Posterior leaflet angle was significantly greater for functional MR (37.9 +/- 19.1 degrees vs. 22.9 +/- 14 degrees , P < 0.018) and less for valvular MR (0.6 +/- 35.5 degrees vs. 22.9 +/- 14 degrees, P < 0.017). Sensitivity, specificity, and positive and negative predictive values of MDCT were 100%, 95%, 96% and 100%. CONCLUSION: Cardiac MDCT allows the differentiation between functional and valvular causes of MR.
- Mechanism of atrial functional mitral regurgitation in patients with atrial fibrillation: A study using three-dimensional transesophageal echocardiography.
- Authors: Ito K, Abe Y, Takahashi Y, Shimada Y, Fukumoto H, Matsumura Y, Naruko T, Shibata T, Yoshiyama M, Yoshikawa J
- Issue date: 2017 Dec
- Effects of cardiac resynchronization therapy after inferior myocardial infarction on secondary mitral regurgitation and mitral valve geometry.
- Authors: Mihos CG, Yucel E, Capoulade R, Orencole MP, Upadhyay GA, Santana O, Singh JP, Picard MH
- Issue date: 2018 Feb
- Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling.
- Authors: Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA
- Issue date: 2017 Nov
- Incremental value of global systolic dyssynchrony in determining the occurrence of functional mitral regurgitation in patients with left ventricular systolic dysfunction.
- Authors: Liang YJ, Zhang Q, Fang F, Lee AP, Liu M, Yan BP, Lam YY, Chan GC, Yu CM
- Issue date: 2013 Mar
- Three-dimensional remodeling of mitral valve in patients with significant regurgitation secondary to rheumatic versus prolapse etiology.
- Authors: Song JM, Jung YJ, Jung YJ, Ji HW, Kim DH, Kang DH, Song JK
- Issue date: 2013 Jun 1