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    Development of a preliminary composite disease activity index in psoriatic arthritis.

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    Authors
    Mumtaz, Aizad
    Gallagher, Phil
    Kirby, Brian
    Waxman, Robin
    Coates, Laura C
    Veale J, Douglas
    Helliwell, Philip
    FitzGerald, Oliver
    Affiliation
    Department of Rheumatology, St Vincent's University Hospital, University College , Dublin, Dublin, Ireland.
    Issue Date
    2012-02-01T10:32:48Z
    MeSH
    Adult
    Aged
    Antirheumatic Agents/therapeutic use
    Arthritis, Psoriatic/*diagnosis/drug therapy
    Drug Monitoring/methods
    Epidemiologic Methods
    Female
    Humans
    Male
    Middle Aged
    Psoriasis/diagnosis/drug therapy
    Quality of Life
    *Severity of Illness Index
    Treatment Outcome
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    Citation
    Ann Rheum Dis. 2011 Feb;70(2):272-7. Epub 2010 Nov 29.
    Journal
    Annals of the rheumatic diseases
    URI
    http://hdl.handle.net/10147/207610
    DOI
    10.1136/ard.2010.129379
    PubMed ID
    21115550
    Abstract
    OBJECTIVES: To develop a preliminary composite psoriatic disease activity index (CPDAI) for psoriasis and psoriatic arthritis. METHODS: Five domains were assessed and specific instruments were employed for each domain to determine the extent of domain involvement and the effect of that involvement on quality of life/function. Disease activity for each domain was then graded from 0 to 3 giving a CPDAI range of 0-15. Patient and physician global disease activity measures were also recorded and an independent physician was asked to indicate if treatment change was required. Bivariate correlation analysis was performed. Factor, tree analysis and standardised response means were also calculated. RESULTS: Significant correlation was seen between CPDAI and both patient (r = 0.834) and physician (r = 0.825) global disease activity assessments (p = 0.01). Tree analysis revealed that 96.3% of patients had their treatment changed when CPDAI values were greater than 6; no patient had their treatment changed when CPDAI values were less than 5. CONCLUSION: CPDAI correlates well with patient and physician global disease activity assessments and is an effective tool that clearly distinguishes those who require a treatment change from those who do not.
    Language
    eng
    ISSN
    1468-2060 (Electronic)
    0003-4967 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1136/ard.2010.129379
    Scopus Count
    Collections
    St. Vincent's University Hospital

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