AffiliationDepartment of Pathology and Laboratory Medicine, St. Vincent's University, Hospital, Dublin 4, Ireland. Michael.J.Duffy@ucd.ie
Amino Acid Sequence
MetadataShow full item record
CitationClin Chim Acta. 2009 May;403(1-2):31-6.
JournalClinica chimica acta; international journal of clinical chemistry
AbstractThe ADAMs are a family of multidomain transmembrane and secreted proteins involved in both proteolysis and cell adhesion. Altered expression of specific ADAMs is implicated in the pathophysiology of several diseases including rheumatoid arthritis, Alzheimer's disease, cardiac hypertrophy, asthma and cancer. Of these different diseases, it is in cancer where most research has been carried out. Multiple ADAMs, including ADAM-9, ADAM-10, ADAM-12, ADAM-15 and ADAM-17, have been shown to play a role in either cancer formation or progression. Consistent with these findings, increased expression of specific ADAMs in several cancer types was found to correlate with features of aggressive disease and poor prognosis. Currently, selective ADAM inhibitors against ADAM-10 and ADAM-17 are undergoing clinical trials for the treatment of cancer. Further work is required in order to establish a causative role for ADAMs in rheumatoid arthritis, Alzheimer's disease, cardiac hypertrophy and asthma.
- Role of ADAMs in cancer formation and progression.
- Authors: Duffy MJ, McKiernan E, O'Donovan N, McGowan PM
- Issue date: 2009 Feb 15
- The ADAM metalloproteinases.
- Authors: Edwards DR, Handsley MM, Pennington CJ
- Issue date: 2008 Oct
- ADAMs family and relatives in cardiovascular physiology and pathology.
- Authors: Zhang P, Shen M, Fernandez-Patron C, Kassiri Z
- Issue date: 2016 Apr
- The ADAMs family of proteases as targets for the treatment of cancer.
- Authors: Mullooly M, McGowan PM, Crown J, Duffy MJ
- Issue date: 2016 Aug 2
- Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.
- Authors: Hsia HE, Tüshaus J, Brummer T, Zheng Y, Scilabra SD, Lichtenthaler SF
- Issue date: 2019 Aug