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dc.contributor.authorLynch, Lydia A
dc.contributor.authorO'Connell, Jean M
dc.contributor.authorKwasnik, Anna K
dc.contributor.authorCawood, Thomas J
dc.contributor.authorO'Farrelly, Cliona
dc.contributor.authorO'Shea, Donal B
dc.date.accessioned2012-02-01T10:31:59Z
dc.date.available2012-02-01T10:31:59Z
dc.date.issued2012-02-01T10:31:59Z
dc.identifier.citationObesity (Silver Spring). 2009 Mar;17(3):601-5. Epub 2008 Dec 18.en_GB
dc.identifier.issn1930-7381 (Print)en_GB
dc.identifier.issn1930-7381 (Linking)en_GB
dc.identifier.pmid19238145en_GB
dc.identifier.doi10.1038/oby.2008.565en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207581
dc.description.abstractWith the emerging obesity pandemic, identifying those who appear to be protected from adverse consequences such as type 2 diabetes and certain malignancies will become important. We propose that the circulating immune system plays a role in the development of these comorbidities. Clinical data and blood samples were collected from 52 patients with severe obesity attending a hospital weight-management clinic and 11 lean healthy controls. Patients were classified into metabolically "healthy obese" (n = 26; mean age 42.6 years, mean BMI 46.8 kg/m(2)) or "unhealthy obese" (n = 26; mean age 45 years, mean BMI 47.5 kg/m(2)) groups, based upon standard cutoff points for blood pressure, lipid profile, and fasting glucose. Circulating lymphoid populations and phenotypes were assessed by flow cytometry. Obese patients had significantly less circulating natural killer (NK) and cytotoxic T lymphocytes (CTL) compared to lean controls. There were significantly higher levels of NK cells and CTLs in the healthy obese group compared to the unhealthy obese group (NK: 11.7% vs. 6.5%, P < 0.0001, CD8 13.4% vs. 9.3%, P = 0.04), independent of age and BMI and these NK cells were also less activated in the healthy compared to the unhealthy group (CD69, 4.1% vs. 11.8%, P = 0.03). This is the first time that quantitative differences in the circulating immune system of obese patients with similar BMI but different metabolic profiles have been described. The significantly higher levels of CTLs and NK cells, which express fewer inhibitory molecules, could protect against malignancy, infection, and metabolic disease seen in obesity.
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshCell Survivalen_GB
dc.subject.meshDiabetes Mellitus, Type 2/epidemiology/metabolismen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmune System/*physiologyen_GB
dc.subject.meshKiller Cells, Natural/*physiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshObesity/complications/*metabolismen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshT-Lymphocytes, Cytotoxic/physiologyen_GB
dc.subject.meshYoung Adulten_GB
dc.titleAre natural killer cells protecting the metabolically healthy obese patient?en_GB
dc.contributor.departmentDepartment of Obesity and Immunology, St. Vincent's University Hospital, Dublin, , Ireland. Lydia.lynch@ucd.ieen_GB
dc.identifier.journalObesity (Silver Spring, Md.)en_GB
dc.description.provinceLeinster
html.description.abstractWith the emerging obesity pandemic, identifying those who appear to be protected from adverse consequences such as type 2 diabetes and certain malignancies will become important. We propose that the circulating immune system plays a role in the development of these comorbidities. Clinical data and blood samples were collected from 52 patients with severe obesity attending a hospital weight-management clinic and 11 lean healthy controls. Patients were classified into metabolically "healthy obese" (n = 26; mean age 42.6 years, mean BMI 46.8 kg/m(2)) or "unhealthy obese" (n = 26; mean age 45 years, mean BMI 47.5 kg/m(2)) groups, based upon standard cutoff points for blood pressure, lipid profile, and fasting glucose. Circulating lymphoid populations and phenotypes were assessed by flow cytometry. Obese patients had significantly less circulating natural killer (NK) and cytotoxic T lymphocytes (CTL) compared to lean controls. There were significantly higher levels of NK cells and CTLs in the healthy obese group compared to the unhealthy obese group (NK: 11.7% vs. 6.5%, P < 0.0001, CD8 13.4% vs. 9.3%, P = 0.04), independent of age and BMI and these NK cells were also less activated in the healthy compared to the unhealthy group (CD69, 4.1% vs. 11.8%, P = 0.03). This is the first time that quantitative differences in the circulating immune system of obese patients with similar BMI but different metabolic profiles have been described. The significantly higher levels of CTLs and NK cells, which express fewer inhibitory molecules, could protect against malignancy, infection, and metabolic disease seen in obesity.


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