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    Use of molecular markers for predicting therapy response in cancer patients.

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    Authors
    Duffy, Michael J
    O'Donovan, Norma
    Crown, John
    Affiliation
    Department of Pathology and Laboratory Medicine, St. Vincent's University, Hospital, Dublin, Ireland. Michael.J.Duffy@ucd.ie
    Issue Date
    2012-02-01T10:31:55Z
    MeSH
    Antibodies, Monoclonal/therapeutic use
    Antibodies, Monoclonal, Humanized
    Biological Markers/analysis
    Breast Neoplasms/chemistry/*drug therapy/genetics
    Cytochrome P-450 CYP2D6/genetics
    Female
    Genotype
    Humans
    Individualized Medicine
    Mutation
    Proto-Oncogene Proteins/genetics
    Quinazolines/therapeutic use
    Receptor, Epidermal Growth Factor/analysis/genetics
    Receptor, erbB-2/analysis
    Receptors, Estrogen/analysis
    Receptors, Progesterone/analysis
    Tamoxifen/therapeutic use
    ras Proteins/genetics
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    Citation
    Cancer Treat Rev. 2011 Apr;37(2):151-9. Epub 2010 Aug 3.
    Journal
    Cancer treatment reviews
    URI
    http://hdl.handle.net/10147/207579
    DOI
    10.1016/j.ctrv.2010.07.004
    PubMed ID
    20685042
    Abstract
    Predictive markers are factors that are associated with upfront response or resistance to a particular therapy. Predictive markers are important in oncology as tumors of the same tissue of origin vary widely in their response to most available systemic therapies. Currently recommended oncological predictive markers include both estrogen and progesterone receptors for identifying patients with breast cancers likely to benefit from hormone therapy, HER-2 for the identification of breast cancer patients likely to benefit from trastuzumab, specific K-RAS mutations for the identification of patients with advanced colorectal cancer unlikely to benefit from either cetuximab or panitumumab and specific EGFR mutations for selecting patients with advanced non-small-cell lung cancer for treatment with tyrosine kinase inhibitors such as gefitinib and erlotinib. The availability of predictive markers should increase drug efficacy and decrease toxicity, thus leading to a more personalized approach to cancer treatment.
    Language
    eng
    ISSN
    1532-1967 (Electronic)
    0305-7372 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctrv.2010.07.004
    Scopus Count
    Collections
    St. Vincent's University Hospital

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