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    Profiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care.

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    Authors
    Jan, A
    Murphy, N F
    O'Loughlin, C
    Ledwidge, M
    McDonald, K
    Affiliation
    Department of Cardiology, Heart Failure Unit, St. Vincent's University Hospital, and University College Dublin, Elm Park, Dublin 4, Ireland.
    Issue Date
    2012-02-01T10:31:43Z
    MeSH
    Aged
    Aged, 80 and over
    Female
    Heart Failure/*blood/mortality
    Hospitalization
    Humans
    Male
    Middle Aged
    Natriuretic Peptide, Brain/*blood
    Predictive Value of Tests
    Prognosis
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    Citation
    Ir J Med Sci. 2011 Jun;180(2):355-62. Epub 2011 Mar 3.
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/207572
    DOI
    10.1007/s11845-011-0689-1
    PubMed ID
    21369749
    Abstract
    AIM: To examine the prognostic importance of absolute values and change in values of BNP in patients with stable heart failure (HF). METHODS: Five-hundred and fifty-nine patients attending a disease management programme were categorized into tertiles of BNP (group 1; /= 250 pg/ml). A change in BNP between two stable visits was recorded. Patients were followed up for 1 year for death and a composite morbidity measure of HF hospitalization, all-cause hospitalization, unscheduled visits for clinical deterioration(UC) of HF using survival analysis. RESULTS: The risk of the combined morbidity outcome increased with increasing tertiles of BNP (Log rank = 17.8 (2), p < 0.001). Furthermore, a 50 and 25% increase in BNP predicted morbidity in stable HF patients with an initial BNP > 200 pg/ml (p = 0.02) and > 450 pg/ml (p = 0.03), respectively. CONCLUSION: In a stable community HF population, an elevated BNP or an increase in BNP predicts an adverse prognosis thereby potentially identifying a population in need of closer clinical follow-up.
    Language
    eng
    ISSN
    1863-4362 (Electronic)
    0021-1265 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-011-0689-1
    Scopus Count
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    St. Vincent's University Hospital

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