Late-onset progressive visual loss in a man with unusual MRI findings: MS, Harding's, Leber's or Leber's Plus?
Affiliation
Department of Neurology, St. Vincent's University Hospital, Elm Park, Dublin 4,, Ireland.Issue Date
2012-02-01T10:31:21ZMeSH
AgedDisease Progression
Humans
*Magnetic Resonance Imaging
Male
Multiple Sclerosis/diagnosis
Mutation
Optic Atrophy, Hereditary, Leber/*diagnosis/genetics
Vision Disorders/etiology/genetics
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Ir J Med Sci. 2010 Dec;179(4):599-601. Epub 2010 Oct 1.Journal
Irish journal of medical scienceDOI
10.1007/s11845-010-0586-zPubMed ID
20882363Abstract
Leber's hereditary optic neuropathy (LHON) is a maternally inherited disorder, typically presenting in the second and third decade. We report the case of an elderly gentleman with significant vascular risk factors, presenting with slowly progressive, bilateral, visual loss with high signal lesions in the pericallosal and periventricular deep white matter on MRI brain studies. Possible diagnoses included late-onset MS, ischaemic optic neuropathies, a mitochondrial disorder or an overlap syndrome such as Harding's disease.Language
engISSN
1863-4362 (Electronic)0021-1265 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1007/s11845-010-0586-z
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