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dc.contributor.authorWhelan, R
dc.contributor.authorLonergan, R
dc.contributor.authorKiiski, H
dc.contributor.authorNolan, H
dc.contributor.authorKinsella, K
dc.contributor.authorBramham, J
dc.contributor.authorO'Brien, M
dc.contributor.authorReilly, R B
dc.contributor.authorHutchinson, M
dc.contributor.authorTubridy, N
dc.date.accessioned2012-02-01T10:30:32Z
dc.date.available2012-02-01T10:30:32Z
dc.date.issued2012-02-01T10:30:32Z
dc.identifier.citationClin Neurophysiol. 2010 Sep;121(9):1420-6. Epub 2010 Apr 8.en_GB
dc.identifier.issn1872-8952 (Electronic)en_GB
dc.identifier.issn1388-2457 (Linking)en_GB
dc.identifier.pmid20381418en_GB
dc.identifier.doi10.1016/j.clinph.2010.03.019en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207533
dc.description.abstractOBJECTIVE: To quantify latency, amplitude and topographical differences in event-related potential (ERP) components between multiple sclerosis (MS) patients and controls and to compare ERP findings with results from the paced auditory serial addition test (PASAT). METHODS: Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16 secondary progressive (SPMS) patients, and 21 controls) completed visual and auditory oddball tasks while data were recorded from 134 EEG channels. Latency and amplitude differences, calculated using composite mean amplitude measures, were tested using an ANOVA. Topographical differences were tested using statistical parametric mapping (SPM). RESULTS: In the visual modality, P2, P3 amplitudes and N2 latency were significantly different across groups. In the auditory modality, P2, N2, and P3 latencies and N1 amplitude were significantly different across groups. There were no significant differences between RRMS and SPMS patients on any ERP component. There were topographical differences between MS patients and controls for both early and late components for the visual modality, but only in the early components for the auditory modality. PASAT score correlated significantly with auditory P3 latency for MS patients. CONCLUSIONS: There were significant ERP differences between MS patients and controls. SIGNIFICANCE: The present study indicated that both early sensory and later cognitive ERP components are impaired in MS patients relative to controls.
dc.language.isoengen_GB
dc.subject.meshAcoustic Stimulation/methodsen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnalysis of Varianceen_GB
dc.subject.mesh*Brain Mappingen_GB
dc.subject.meshDisability Evaluationen_GB
dc.subject.meshElectroencephalography/methodsen_GB
dc.subject.meshEvoked Potentials/*physiologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFunctional Laterality/physiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMultiple Sclerosis/*pathology/*physiopathologyen_GB
dc.subject.meshPhotic Stimulation/methodsen_GB
dc.subject.meshReaction Time/*physiologyen_GB
dc.titleA high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls.en_GB
dc.contributor.departmentDepartment of Neurology, St. Vincent's University Hospital/University College, Dublin, Ireland. Robert.whelan@tcd.ieen_GB
dc.identifier.journalClinical neurophysiology : official journal of the International Federation of, Clinical Neurophysiologyen_GB
dc.description.provinceLeinster
html.description.abstractOBJECTIVE: To quantify latency, amplitude and topographical differences in event-related potential (ERP) components between multiple sclerosis (MS) patients and controls and to compare ERP findings with results from the paced auditory serial addition test (PASAT). METHODS: Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16 secondary progressive (SPMS) patients, and 21 controls) completed visual and auditory oddball tasks while data were recorded from 134 EEG channels. Latency and amplitude differences, calculated using composite mean amplitude measures, were tested using an ANOVA. Topographical differences were tested using statistical parametric mapping (SPM). RESULTS: In the visual modality, P2, P3 amplitudes and N2 latency were significantly different across groups. In the auditory modality, P2, N2, and P3 latencies and N1 amplitude were significantly different across groups. There were no significant differences between RRMS and SPMS patients on any ERP component. There were topographical differences between MS patients and controls for both early and late components for the visual modality, but only in the early components for the auditory modality. PASAT score correlated significantly with auditory P3 latency for MS patients. CONCLUSIONS: There were significant ERP differences between MS patients and controls. SIGNIFICANCE: The present study indicated that both early sensory and later cognitive ERP components are impaired in MS patients relative to controls.


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