A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls.
Reilly, R B
AffiliationDepartment of Neurology, St. Vincent's University Hospital/University College, Dublin, Ireland. Robert.firstname.lastname@example.org
Analysis of Variance
MetadataShow full item record
CitationClin Neurophysiol. 2010 Sep;121(9):1420-6. Epub 2010 Apr 8.
JournalClinical neurophysiology : official journal of the International Federation of, Clinical Neurophysiology
AbstractOBJECTIVE: To quantify latency, amplitude and topographical differences in event-related potential (ERP) components between multiple sclerosis (MS) patients and controls and to compare ERP findings with results from the paced auditory serial addition test (PASAT). METHODS: Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16 secondary progressive (SPMS) patients, and 21 controls) completed visual and auditory oddball tasks while data were recorded from 134 EEG channels. Latency and amplitude differences, calculated using composite mean amplitude measures, were tested using an ANOVA. Topographical differences were tested using statistical parametric mapping (SPM). RESULTS: In the visual modality, P2, P3 amplitudes and N2 latency were significantly different across groups. In the auditory modality, P2, N2, and P3 latencies and N1 amplitude were significantly different across groups. There were no significant differences between RRMS and SPMS patients on any ERP component. There were topographical differences between MS patients and controls for both early and late components for the visual modality, but only in the early components for the auditory modality. PASAT score correlated significantly with auditory P3 latency for MS patients. CONCLUSIONS: There were significant ERP differences between MS patients and controls. SIGNIFICANCE: The present study indicated that both early sensory and later cognitive ERP components are impaired in MS patients relative to controls.
- Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: a high-density EEG study.
- Authors: Whelan R, Lonergan R, Kiiski H, Nolan H, Kinsella K, Hutchinson M, Tubridy N, Reilly RB
- Issue date: 2010 Jun 15
- Cluster analysis of behavioural and event-related potentials during a contingent negative variation paradigm in remitting-relapsing and benign forms of multiple sclerosis.
- Authors: Gonzalez-Rosa JJ, Vazquez-Marrufo M, Vaquero E, Duque P, Borges M, Gomez-Gonzalez CM, Izquierdo G
- Issue date: 2011 Jun 2
- Change in PASAT performance correlates with change in P3 ERP amplitude over a 12-month period in multiple sclerosis patients.
- Authors: Kiiski H, Reilly RB, Lonergan R, Kelly S, O'Brien M, Kinsella K, Bramham J, Burke T, O'Donnchadha S, Nolan H, Hutchinson M, Tubridy N, Whelan R
- Issue date: 2011 Jun 15
- Preliminary evidence for correlation between PASAT performance and P3a and P3b amplitudes in progressive multiple sclerosis.
- Authors: Kiiski H, Whelan R, Lonergan R, Nolan H, Kinsella K, Hutchinson M, Tubridy N, Reilly RB
- Issue date: 2011 May
- Multichannel auditory event-related brain potentials: effects of normal aging on the scalp distribution of N1, P2, N2 and P300 latencies and amplitudes.
- Authors: Anderer P, Semlitsch HV, Saletu B
- Issue date: 1996 Nov