AffiliationDepartment of Endocrinology and Diabetes, Our Ladys Childrens Hospital, Crumlin, , Dublin, Ireland.
Genetic Predisposition to Disease
Hormone Replacement Therapy/methods
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CitationArch Dis Child. 2011 Mar;96(3):280-4. Epub 2010 Apr 22.
JournalArchives of disease in childhood
AbstractSubclinical hypothyroidism (SH) is defined as an elevated thyroid stimulating hormone (TSH) in association with a normal total or free thyroxine (T4) or triiodothyronine (T3). It is frequently encountered in both neonatology and general paediatric practice; however, its clinical significance is widely debated. Currently there is no broad consensus on the investigation and treatment of these patients; specifically who to treat and what cut-off level of TSH should be used. This paper reviews the available evidence regarding investigation, treatments and outcomes reported for childhood SH.
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