Affiliation
Department of Endocrinology and Diabetes, Our Ladys Childrens Hospital, Crumlin, , Dublin, Ireland.Issue Date
2012-02-01T10:24:24ZMeSH
ChildChild, Preschool
Down Syndrome/complications
Genetic Predisposition to Disease
Hormone Replacement Therapy/methods
Humans
Hypothyroidism/*diagnosis/drug therapy/etiology
Infant
Infant, Newborn
Thyrotropin/blood
Thyroxine/therapeutic use
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Arch Dis Child. 2011 Mar;96(3):280-4. Epub 2010 Apr 22.Journal
Archives of disease in childhoodDOI
10.1136/adc.2009.181800PubMed ID
20413616Abstract
Subclinical hypothyroidism (SH) is defined as an elevated thyroid stimulating hormone (TSH) in association with a normal total or free thyroxine (T4) or triiodothyronine (T3). It is frequently encountered in both neonatology and general paediatric practice; however, its clinical significance is widely debated. Currently there is no broad consensus on the investigation and treatment of these patients; specifically who to treat and what cut-off level of TSH should be used. This paper reviews the available evidence regarding investigation, treatments and outcomes reported for childhood SH.Language
engISSN
1468-2044 (Electronic)0003-9888 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1136/adc.2009.181800
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