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    Esophageal strictures during treatment for acute lymphoblastic leukemia.

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    Authors
    Kelly, Kevin
    Storey, Lorna
    O' Sullivan, Maureen
    Butler, Karina
    McDermott, Michael
    Corbally, Martin
    McMahon, Corrina
    Smith, Owen P
    O' Marcaigh, Aengus
    Affiliation
    Departments of Haematology, Our Lady's Children's Hospital, Crumlin, Dublin,, Ireland. kevrkelly77@hotmail.com
    Issue Date
    2012-02-01T10:24:11Z
    MeSH
    Antifungal Agents/therapeutic use
    Antineoplastic Agents/adverse effects
    Candidiasis/complications
    Child
    Child, Preschool
    Dexamethasone/adverse effects
    Esophageal Stenosis/*etiology
    Female
    Humans
    Infant
    Male
    Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
    Radiotherapy/adverse effects
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    Citation
    J Pediatr Hematol Oncol. 2010 Mar;32(2):124-7.
    Journal
    Journal of pediatric hematology/oncology
    URI
    http://hdl.handle.net/10147/207406
    DOI
    10.1097/MPH.0b013e3181ced25c
    PubMed ID
    20168244
    Abstract
    Esophageal stricture is a rare complication of paediatric cancer treatment that usually occurs after esophageal exposure to radiotherapy. We describe 4 cases of esophageal stricture during chemotherapy for acute lymphoblastic leukemia. All patients presented with refractory vomiting and were diagnosed with radiologic contrast studies. None of the patients had received radiotherapy. Esophageal candidiasis was seen in 2 patients but the remaining 2 patients had earlier systemic candidiasis. High-dose dexamethasone may predispose these children to both esophageal candidiasis and peptic esophagitis. The etiology of esophageal strictures during treatment for acute leukemia is likely to be multifactorial but systemic candidiasis may play a significant role.
    Language
    eng
    ISSN
    1536-3678 (Electronic)
    1077-4114 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1097/MPH.0b013e3181ced25c
    Scopus Count
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    Children's Health Ireland (CHI) at Crumlin

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