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    SLPI and inflammatory lung disease in females.

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    Authors
    McKiernan, Paul J
    McElvaney, Noel G
    Greene, Catherine M
    Affiliation
    Department of Medicine, Respiratory Research Royal College of Surgeons in, Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
    Issue Date
    2012-02-01T10:05:14Z
    MeSH
    Animals
    Bronchi/drug effects
    Cystic Fibrosis/metabolism/physiopathology
    Estrogens/metabolism/pharmacology
    Female
    Gene Expression Regulation
    Humans
    Inflammation/*metabolism
    Lung Diseases/*metabolism/physiopathology
    MicroRNAs/genetics/metabolism
    Secretory Leukocyte Peptidase Inhibitor/*metabolism
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    Metadata
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    Citation
    Biochem Soc Trans. 2011 Oct;39(5):1421-6.
    Journal
    Biochemical Society transactions
    URI
    http://hdl.handle.net/10147/207340
    DOI
    10.1042/BST0391421
    PubMed ID
    21936826
    Abstract
    During the course of certain inflammatory lung diseases, SLPI (secretory leucoprotease inhibitor) plays a number of important roles. As a serine antiprotease it functions to protect the airways from proteolytic damage due to neutrophil and other immune cell-derived serine proteases. With respect to infection it has known antimicrobial and anti-viral properties that are likely to contribute to host defence. Another of its properties is the ability to control inflammation within the lung where it can interfere with the transcriptional induction of pro-inflammatory gene expression induced by NF-kappaB (nuclear factor kappaB). Thus, factors that regulate the expression of SLPI in the airways can impact on disease severity and outcome. Gender represents once such idiosyncratic factor. In females with CF (cystic fibrosis), it is now thought that circulating oestrogen contributes, in part, to the observed gender gap whereby females have worse disease and poorer prognosis than males. Conversely, in asthma, sufferers who are females have more frequent exacerbations at times of low-circulating oestrogen. In the present paper, we discuss how SLPI participates in these events and speculate on whether regulatory mechanisms such as post-transcriptional modulation by miRNAs (microRNAs) are important in the control of SLPI expression in inflammatory lung disease.
    Language
    eng
    ISSN
    1470-8752 (Electronic)
    0300-5127 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1042/BST0391421
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

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