Malignant melanoma and breast carcinoma: a bidirectional correlation.
AffiliationDepartment of Dermatology, Beaumont Hospital, Dublin 9, Ireland. email@example.com
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CitationIr J Med Sci. 2011 Dec;180(4):901-3. Epub 2009 Mar 5.
JournalIrish journal of medical science
AbstractBACKGROUND: Epidemiologic and genetic studies have suggested a bidirectional association between breast carcinoma (BC) and malignant melanoma (MM). OBSERVATION: We present a series of patients with MM and BC detected in our department within a span of 6 months, raising concerns for the high associations between the two malignancies. This led us to match the concordance of the two tumours in the National Irish Cancer Registry. CONCLUSION: The national figures provide evidence of a link between BC and MM. We recommend increased awareness among clinicians leading to more detailed surveillance of both second primary tumours. All MM patients with a family history of BC should be referred to a breast clinic. Women above the age of 40 with MM should undergo annual mammography and those less than 40 may be better evaluated with a breast MRI. All breast cancer patients should be made aware of the significance of changing moles and those with suspicious lesions referred to a dermatologist for evaluation.