Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
AuthorsBehan, Aine T
van den Hove, Daniel L A
Jetten, Marlon J A
Steinbusch, Harry W M
Cotter, David R
AffiliationDepartment of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education, and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland., firstname.lastname@example.org
Disease Models, Animal
*Prenatal Exposure Delayed Effects
MetadataShow full item record
CitationEur Neuropsychopharmacol. 2011 Jan;21(1):71-9. Epub 2010 Aug 10.
JournalEuropean neuropsychopharmacology : the journal of the European College of, Neuropsychopharmacology
AbstractPrenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
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