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dc.contributor.authorThomas, Warren
dc.contributor.authorHarvey, Brian J
dc.date.accessioned2012-02-01T10:02:54Z
dc.date.available2012-02-01T10:02:54Z
dc.date.issued2012-02-01T10:02:54Z
dc.identifier.citationAnnu Rev Physiol. 2011 Mar 17;73:335-57.en_GB
dc.identifier.issn1545-1585 (Electronic)en_GB
dc.identifier.issn0066-4278 (Linking)en_GB
dc.identifier.pmid20809792en_GB
dc.identifier.doi10.1146/annurev-physiol-012110-142222en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207243
dc.description.abstractThe steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.
dc.language.isoengen_GB
dc.subject.meshAldosterone/*physiologyen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshBiological Transport/physiologyen_GB
dc.subject.meshEpithelial Sodium Channel/physiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshKidney/*physiologyen_GB
dc.subject.meshMiceen_GB
dc.subject.meshProtein Kinases/physiologyen_GB
dc.subject.meshRatsen_GB
dc.subject.meshReceptors, Aldosterone/*physiologyen_GB
dc.subject.meshReceptors, Growth Factor/physiologyen_GB
dc.subject.meshSignal Transduction/physiologyen_GB
dc.subject.meshSodium-Potassium-Exchanging ATPase/physiologyen_GB
dc.subject.meshTranscription, Genetic/physiologyen_GB
dc.titleMechanisms underlying rapid aldosterone effects in the kidney.en_GB
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont , Hospital, Dublin, Ireland. wthomas@rcsi.ieen_GB
dc.identifier.journalAnnual review of physiologyen_GB
dc.description.provinceLeinster
html.description.abstractThe steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.


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