Affiliation
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont , Hospital, Dublin, Ireland. wthomas@rcsi.ieIssue Date
2012-02-01T10:02:54ZMeSH
Aldosterone/*physiologyAnimals
Biological Transport/physiology
Epithelial Sodium Channel/physiology
Humans
Kidney/*physiology
Mice
Protein Kinases/physiology
Rats
Receptors, Aldosterone/*physiology
Receptors, Growth Factor/physiology
Signal Transduction/physiology
Sodium-Potassium-Exchanging ATPase/physiology
Transcription, Genetic/physiology
Metadata
Show full item recordCitation
Annu Rev Physiol. 2011 Mar 17;73:335-57.Journal
Annual review of physiologyDOI
10.1146/annurev-physiol-012110-142222PubMed ID
20809792Abstract
The steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.Language
engISSN
1545-1585 (Electronic)0066-4278 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1146/annurev-physiol-012110-142222
Scopus Count
Collections
Related articles
- Rapid responses to aldosterone in the kidney and colon.
- Authors: Harvey BJ, Alzamora R, Stubbs AK, Irnaten M, McEneaney V, Thomas W
- Issue date: 2008 Feb
- Rapid aldosterone actions on epithelial sodium channel trafficking and cell proliferation.
- Authors: Quinn S, Harvey BJ, Thomas W
- Issue date: 2014 Mar
- Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.
- Authors: Le Moëllic C, Ouvrard-Pascaud A, Capurro C, Cluzeaud F, Fay M, Jaisser F, Farman N, Blot-Chabaud M
- Issue date: 2004 May
- Mechanisms of mineralocorticoid action.
- Authors: Fuller PJ, Young MJ
- Issue date: 2005 Dec
- [Aldosterone: the mechanisms of molecular action].
- Authors: Logvinenko NS
- Issue date: 2007 Jul