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    Mechanisms underlying rapid aldosterone effects in the kidney.

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    Authors
    Thomas, Warren
    Harvey, Brian J
    Affiliation
    Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont , Hospital, Dublin, Ireland. wthomas@rcsi.ie
    Issue Date
    2012-02-01T10:02:54Z
    MeSH
    Aldosterone/*physiology
    Animals
    Biological Transport/physiology
    Epithelial Sodium Channel/physiology
    Humans
    Kidney/*physiology
    Mice
    Protein Kinases/physiology
    Rats
    Receptors, Aldosterone/*physiology
    Receptors, Growth Factor/physiology
    Signal Transduction/physiology
    Sodium-Potassium-Exchanging ATPase/physiology
    Transcription, Genetic/physiology
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    Metadata
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    Citation
    Annu Rev Physiol. 2011 Mar 17;73:335-57.
    Journal
    Annual review of physiology
    URI
    http://hdl.handle.net/10147/207243
    DOI
    10.1146/annurev-physiol-012110-142222
    PubMed ID
    20809792
    Abstract
    The steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.
    Language
    eng
    ISSN
    1545-1585 (Electronic)
    0066-4278 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1146/annurev-physiol-012110-142222
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

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