Nanotechnology and its relationship to interventional radiology. Part II: Drug Delivery, Thermotherapy, and Vascular Intervention.
AffiliationDepartment of Radiology, Beaumont Hospital, Beaumont Road, PO Box 1297, Dublin 9,, Ireland.
MeSHAntineoplastic Agents/administration & dosage
Drug Delivery Systems/*methods
Muscle, Smooth, Vascular/drug effects
MetadataShow full item record
CitationCardiovasc Intervent Radiol. 2011 Aug;34(4):676-90. Epub 2010 Sep 16.
JournalCardiovascular and interventional radiology
AbstractNanotechnology can be defined as the design, creation, and manipulation of structures on the nanometer scale. This two-part review is intended to acquaint the interventionalist with the field of nanotechnology, and provide an overview of potential applications, while highlighting advances relevant to interventional radiology. Part 2 of the article concentrates on drug delivery, thermotherapy, and vascular intervention. In oncology, advances in drug delivery allow for improved efficacy, decreased toxicity, and greater potential for targeted therapy. Magnetic nanoparticles show potential for use in thermotherapy treatments of various tumours, and the effectiveness of radiofrequency ablation can be enhanced with nanoparticle chemotherapy agents. In vascular intervention, much work is focused on prevention of restenosis through developments in stent technology and systems for localised drug delivery to vessel walls. Further areas of interest include applications for thrombolysis and haemostasis.
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