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    Pandemic H1N1 (2009) and renal failure: the experience of the Irish national tertiary referral centre.

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    Authors
    O Brien, F J
    Jairam, S D
    Traynor, C A
    Kennedy, C M
    Power, M
    Denton, M D
    Magee, C
    Conlon, P J
    Affiliation
    Department of Nephrology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland., Frankjobrien@physicians.ie
    Issue Date
    2012-02-01T10:02:21Z
    MeSH
    Acute Kidney Injury/*etiology/therapy/virology
    Adolescent
    Adult
    Aged
    Female
    Humans
    *Influenza A Virus, H1N1 Subtype
    Influenza, Human/*complications
    Ireland
    Male
    Middle Aged
    Multiple Organ Failure
    Renal Replacement Therapy
    Retrospective Studies
    Young Adult
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    Citation
    Ir J Med Sci. 2011 Mar;180(1):135-8. Epub 2010 Oct 20.
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/207223
    DOI
    10.1007/s11845-010-0617-9
    PubMed ID
    20960237
    Abstract
    INTRODUCTION: H1N1 influenza A, was first described in April 2009. A significant cohort of patients from this outbreak developed acute respiratory distress syndrome or pneumonia. H1N1 has since been transmitted across the world. Little has been described on the renal complications of this illness. METHODS: A retrospective review of all patients admitted to our institution with H1N1 infection was carried out from July to November 2009. Renal biochemistry, need for renal replacement therapy and hospital outcome was recorded. RESULTS: Thirty-four patients with H1N1 were admitted. Average length of admission was 10 days (3-84). Eleven patients (32%) developed acute kidney injury (AKI) as defined by the RIFLE criteria (creatinine range 120-610). Four patients required renal replacement therapy, for a range of 10-52 days. Seven patients developed AKI that responded to volume resuscitation. The commonest cause of AKI was sepsis with acute tubular necrosis. CONCLUSION: This study highlights the significance and frequency of renal complications associated with this illness.
    Language
    eng
    ISSN
    1863-4362 (Electronic)
    0021-1265 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-010-0617-9
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    Beaumont Hospital

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