The utility of 99mTc-sestamibi scintigraphy in the localisation of parathyroid adenomas in primary hyperparathyroidism.
Affiliation
Division of Endocrinology, Beaumont Hospital, RCSI Medical School, Dublin 9,, Ireland.Issue Date
2012-02-01T10:02:09ZMeSH
Adenoma/complications/*radionuclide imagingAdult
Aged
Aged, 80 and over
Female
Humans
Hyperparathyroidism, Primary/*etiology
Male
Middle Aged
Parathyroid Neoplasms/complications/*radionuclide imaging
Radiopharmaceuticals/*diagnostic use
Retrospective Studies
Sensitivity and Specificity
Technetium Tc 99m Sestamibi/*diagnostic use
Metadata
Show full item recordCitation
Ir J Med Sci. 2011 Mar;180(1):191-4. Epub 2010 Nov 13.Journal
Irish journal of medical scienceDOI
10.1007/s11845-010-0641-9PubMed ID
21076888Abstract
BACKGROUND: There are conflicting data in the literature about the sensitivity of sestamibi scintigraphy in parathyroid tumour localisation in primary hyperparathyroidism (PHPT). AIM: We aimed to evaluate the overall sensitivity of this modality in parathyroid tumour localisation and to determine clinical and biochemical factors which influence sensitivity of this method. METHODS: We performed a retrospective review of 57 patients with a biochemical diagnosis of PHPT who had sestamibi scintigraphy performed. RESULTS: The sensitivity of sestamibi scanning was 56% in whole group and 63% in those without nodular thyroid disease. Among the patients with confirmed single gland disease (biochemical cure after surgical removal of a single adenoma), sensitivity was 71%. A positive scan was associated with younger age, greater adenoma weight and higher pre-operative serum calcium. Concordance between the sestamibi and neck ultrasonography was 92% accurate in pre-operative tumour localisation. CONCLUSION: Sestamibi scintigraphy was more likely to be positive in younger patients without nodular thyroid disease who have larger parathyroid adenomas with more severe hyperparathyroidism.Language
engISSN
1863-4362 (Electronic)0021-1265 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1007/s11845-010-0641-9