Tight glycaemic control is a key factor in wound healing enhancement strategies in an experimental diabetes mellitus model.
AffiliationDepartment of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital,, Dublin, Ireland. email@example.com
Diabetes Mellitus, Experimental/blood/*physiopathology
Transforming Growth Factor beta1/analysis
MetadataShow full item record
CitationIr J Med Sci. 2011 Mar;180(1):229-36. Epub 2010 Nov 26.
JournalIrish journal of medical science
AbstractBACKGROUND: Diabetes mellitus is a leading cause of impaired wound healing. The aim of this study was to establish a glucose-controlled diabetic wound healing model. METHOD: Sprague-Dawley rats were divided into three groups: Control group (C), Diabetic Non-glucose Controlled group (DNC) and Diabetic glucose Controlled group (DC). RESULTS: Glucose control was achieved using Insulman Rapid (average daily glucose level <10 mmol/L). 18 Sprague-Dawley rats underwent a dorsal skin wound incision and 10 days later were killed. Fresh and fixed wound tensile strength, hydroxyproline and transforming growth factor beta-1 levels were improved in the DC group when compared to the DNC group. The quantity of fibroblasts present was similar in each group. CONCLUSION: This study demonstrates the impact that diabetes has on acute wound healing and suggests that wound modulating agents must be tested in both the tightly glucose-controlled as well as the poorly glucose-controlled diabetic animal models prior to proceeding with translational clinical studies.
- Wound Healing Delay in the ZDSD Rat.
- Authors: Suckow MA, Gobbett TA, Peterson RG
- Issue date: 2017 Jan 2
- Transforming growth factor-beta and insulin-like growth factor-I in relation to diabetes-induced impairment of wound healing.
- Authors: Bitar MS, Labbad ZN
- Issue date: 1996 Feb 15
- Effect of pravastatin on experimental diabetic wound healing.
- Authors: Laing T, Hanson R, Chan F, Bouchier-Hayes D
- Issue date: 2010 Jun 15
- Topical diphenylhydantoin sodium can improve healing in a diabetic incisional animal wound model.
- Authors: Chan FC, Kennedy C, Hanson RP, O'Sullivan B, Kelly J, Bouchier-Hayes D
- Issue date: 2007 Sep
- The diabetic rat as an impaired wound healing model: stimulatory effects of transforming growth factor-beta and basic fibroblast growth factor.
- Authors: Broadley KN, Aquino AM, Hicks B, Ditesheim JA, McGee GS, Demetriou AA, Woodward SC, Davidson JM
- Issue date: 1989-1990