Tight glycaemic control is a key factor in wound healing enhancement strategies in an experimental diabetes mellitus model.
AffiliationDepartment of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital,, Dublin, Ireland. firstname.lastname@example.org
Diabetes Mellitus, Experimental/blood/*physiopathology
Transforming Growth Factor beta1/analysis
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CitationIr J Med Sci. 2011 Mar;180(1):229-36. Epub 2010 Nov 26.
JournalIrish journal of medical science
AbstractBACKGROUND: Diabetes mellitus is a leading cause of impaired wound healing. The aim of this study was to establish a glucose-controlled diabetic wound healing model. METHOD: Sprague-Dawley rats were divided into three groups: Control group (C), Diabetic Non-glucose Controlled group (DNC) and Diabetic glucose Controlled group (DC). RESULTS: Glucose control was achieved using Insulman Rapid (average daily glucose level <10 mmol/L). 18 Sprague-Dawley rats underwent a dorsal skin wound incision and 10 days later were killed. Fresh and fixed wound tensile strength, hydroxyproline and transforming growth factor beta-1 levels were improved in the DC group when compared to the DNC group. The quantity of fibroblasts present was similar in each group. CONCLUSION: This study demonstrates the impact that diabetes has on acute wound healing and suggests that wound modulating agents must be tested in both the tightly glucose-controlled as well as the poorly glucose-controlled diabetic animal models prior to proceeding with translational clinical studies.
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