• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5081
    UlsterS
    5081
    Connacht
    1698
    Munster
    58
    Leinster
    466

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Warfarin use in hemodialysis patients: what is the risk?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Phelan, P J
    O'Kelly, P
    Holian, J
    Walshe, J J
    Delany, C
    Slaby, J
    Winders, S
    O'Toole, D
    Magee, C
    Conlon, P J
    Affiliation
    Department of Nephrology, Beaumont Hospital, Dublin 9, Ireland., paulphel@gmail.com
    Issue Date
    2012-02-01T10:00:39Z
    MeSH
    Aged
    Anticoagulants/*adverse effects
    Atrial Fibrillation/blood/complications/*drug therapy
    Blood Coagulation/*drug effects
    Brain Ischemia/etiology/*prevention & control
    Erythrocyte Transfusion
    Female
    Hemorrhage/*chemically induced/therapy
    Hospitalization
    Humans
    International Normalized Ratio
    Ireland
    Length of Stay
    Male
    Renal Dialysis/*adverse effects
    Retrospective Studies
    Risk Assessment
    Risk Factors
    Stroke/etiology/*prevention & control
    Warfarin/*adverse effects
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Clin Nephrol. 2011 Mar;75(3):204-11.
    Journal
    Clinical nephrology
    URI
    http://hdl.handle.net/10147/207158
    PubMed ID
    21329630
    Abstract
    BACKGROUND: There is a paucity of data concerning the risks associated with warfarin in hemodialysis (HD) patients. We compared major bleeding episodes in this group with HD patients not receiving warfarin and with a cohort of non-HD patients receiving warfarin. METHODS: A retrospective review of 141 HD patients on warfarin (HDW), 704 HD patients not on warfarin (HDNW) and 3,266 non-dialysis warfarin patients (NDW) was performed. Hospital admissions for hemorrhagic events and ischemic strokes were examined as was hospital length of stay and blood product use. INR variability was also assessed. RESULTS: The incidence rates for major hemorrhage per 100 patient years was 10.8 in the HDW group as compared to 8.0 in the HDNW (p = 0.593) and 2.1 in the NDW (p < 0.001) groups. Mean units of red blood cell transfusions required was higher in patients on dialysis with no significant difference between HDW and HDNW groups. The risk of ischemic stroke per 100 patient years was 1.7 in the HDW group as compared to 0.7 in the HDNW groups (p = 0.636) and 0.4 in the NDW (p = 0.003). The HDW group had higher inter-measurement INR variability compared to the NDW group (p = 0.034). In patients with atrial fibrillation, HDW group had a higher incidence of ischemic stroke than the NDW group (2.2 versus 0.4 events per 100 patient years; p = 0.024). CONCLUSIONS: This study confirms the higher bleeding risk associated with HD/ESRD but suggests that warfarin use in these patients may not add significantly to this risk. We also demonstrated high rates of ischemic stroke in HD patients despite warfarin use. SUMMARY: Our study compares the frequency of major hemorrhage and secondarily, ischemic stroke in HD patients receiving or not receiving warfarin, with non-HD patients receiving warfarin. The major finding was that frequency of hemorrhage was higher in HD patients receiving warfarin than in non-HD patients receiving warfarin, but not different in HD patients with or without warfarin. A secondary finding was that INR variability was significantly higher in HD patients than non-HD patients on warfarin.
    Language
    eng
    ISSN
    0301-0430 (Print)
    0301-0430 (Linking)
    Collections
    Beaumont Hospital

    entitlement

    Related articles

    • Variability of INR and its relationship with mortality, stroke, bleeding and hospitalisations in patients with atrial fibrillation.
    • Authors: Lind M, Fahlén M, Kosiborod M, Eliasson B, Odén A
    • Issue date: 2012 Jan
    • D-Dimer versus International Normalized Ratio of Prothrombin Time in Ischemic Stroke Patients Treated with Sufficient Warfarin.
    • Authors: Yamamoto R, Nakae Y, Tanaka F, Johkura K
    • Issue date: 2016 Jul
    • Optimal intensity of international normalized ratio in warfarin therapy for secondary prevention of stroke in patients with non-valvular atrial fibrillation.
    • Authors: Yasaka M, Minematsu K, Yamaguchi T
    • Issue date: 2001 Dec
    • Causes of Ischemic Stroke in Patients with Non-Valvular Atrial Fibrillation.
    • Authors: Nakamura A, Kuroda J, Ago T, Hata J, Matsuo R, Arakawa S, Kuwashiro T, Yasaka M, Okada Y, Kitazono T, Kamouchi M, Fukuoka Stroke Registry Investigators
    • Issue date: 2016
    • Sex-Specific Comparative Effectiveness of Oral Anticoagulants in Elderly Patients With Newly Diagnosed Atrial Fibrillation.
    • Authors: Palamaner Subash Shantha G, Bhave PD, Girotra S, Hodgson-Zingman D, Mazur A, Giudici M, Chrischilles E, Vaughan Sarrazin MS
    • Issue date: 2017 Apr
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.