Mechanism of sphingosine 1-phosphate- and lysophosphatidic Acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells.
AffiliationDepartment of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, , Dublin 9, Ireland; E-Mails: email@example.com (R.W.C.); firstname.lastname@example.org, (M.M.); email@example.com (M.A.).
MetadataShow full item record
CitationInt J Mol Sci. 2011;12(5):3237-49. Epub 2011 May 17.
JournalInternational journal of molecular sciences
AbstractThe lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via G-protein coupled receptors S1P(1-5) and LPA(1-3) respectively, and are implicated in allergy. Eosinophils accumulate at innervating cholinergic nerves in asthma and adhere to nerve cells via intercellular adhesion molecule-1 (ICAM-1). IMR-32 neuroblastoma cells were used as an in vitro cholinergic nerve cell model. The G(i) coupled receptors S1P(1), S1P(3), LPA(1), LPA(2) and LPA(3) were expressed on IMR-32 cells. Both S1P and LPA induced ERK phosphorylation and ERK- and G(i)-dependent up-regulation of ICAM-1 expression, with differing time courses. LPA also induced ERK- and G(i)-dependent up-regulation of the eosinophil chemoattractant, CCL-26. The eosinophil granule protein eosinophil peroxidase (EPO) induced ERK-dependent up-regulation of transcription of S1P(1), LPA(1), LPA(2) and LPA(3), providing the situation whereby eosinophil granule proteins may enhance S1P- and/or LPA- induced eosinophil accumulation at nerve cells in allergic conditions.
- Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
- Authors: Peyruchaud O
- Issue date: 2009 May
- Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52.
- Authors: Radeke HH, von Wenckstern H, Stoidtner K, Sauer B, Hammer S, Kleuser B
- Issue date: 2005 Mar 1
- Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells.
- Authors: Gibbs TC, Rubio MV, Zhang Z, Xie Y, Kipp KR, Meier KE
- Issue date: 2009 Oct 1
- Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system.
- Authors: Goetzl EJ, Wang W, McGiffert C, Huang MC, Gräler MH
- Issue date: 2004 Aug 15
- The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.
- Authors: Takuwa Y, Takuwa N, Sugimoto N
- Issue date: 2002 Jun