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    Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms.

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    Authors
    Murphy, Therese M
    Ryan, Maria
    Foster, Tom
    Kelly, Chris
    McClelland, Roy
    O'Grady, John
    Corcoran, Eleanor
    Brady, John
    Reilly, Michael
    Jeffers, Anne
    Brown, Katherine
    Maher, Anne
    Bannan, Noreen
    Casement, Alison
    Lynch, Dermot
    Bolger, Sharon
    Tewari, Prerna
    Buckley, Avril
    Quinlivan, Leah
    Daly, Leslie
    Kelleher, Cecily
    Malone, Kevin M
    Show allShow less
    Affiliation
    Department of Psychiatry & Mental Health Research, St. Vincent's University, Hospital, University College Dublin, Elm Park, Dublin 4, Ireland. murphyth@tcd.ie
    Issue Date
    2012-02-01T10:28:30Z
    MeSH
    Adult
    Endophenotypes
    Excitatory Amino Acid Transporter 1/*genetics
    Female
    Genetic Association Studies/*methods
    Genetic Predisposition to Disease/genetics
    Genotype
    Glutamate Plasma Membrane Transport Proteins/*genetics
    Humans
    Male
    Mental Disorders/complications/*genetics/psychology
    Neurotransmitter Agents/genetics
    Polymorphism, Single Nucleotide
    Receptor, Serotonin, 5-HT1B/*genetics
    Receptor, trkB/*genetics
    Risk Factors
    Signal Transduction/genetics
    Suicide, Attempted/*psychology
    Show allShow less
    
    Metadata
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    Citation
    Behav Brain Funct. 2011 Jun 28;7:22.
    Journal
    Behavioral and brain functions : BBF
    URI
    http://hdl.handle.net/10147/207023
    DOI
    10.1186/1744-9081-7-22
    PubMed ID
    21711518
    Abstract
    BACKGROUND: Suicidal behaviour is known to aggregate in families. Patients with psychiatric disorders are at higher risk for suicide attempts (SA), however protective and risk genetic variants for suicide appear to be independent of underlying psychiatric disorders. Here we investigate genetic variants in genes important for neurobiological pathways linked to suicidal behaviour and/or associated endophenotypes, for association with SA among patients with co-existing psychiatric illness. Selected gene-gene and gene-environment interactions were also tested. METHODS: DNA was obtained from bloods of 159 patients (76 suicide attempters and 83 non-attempters), who were profiled for DSM-IV Axis I psychiatric diagnosis. Twenty-eight single nucleotide polymorphisms (SNPs) from 18 candidate genes (COMT, 5-HT2A, 5-HT1A, 5-HTR1B, TPH1, MAO-A, TPH2, DBH, CNR1, BDNF, ABCG1, GABRA5, GABRG2, GABRB2, SLC1A2, SLC1A3, NTRK2, CRHR1) were genotyped. Genotyping was performed by KBioscience. Tests of association between genetic variants and SA were conducted using Chi squared and Armitage Trend tests. Binary logistical regression analyses were performed to evaluate the contribution of individual genetic variants to the prediction of SA, and to examine SNPs for potential gene-gene and gene-environment interactions. RESULTS: Our analysis identified 4 SNPs (rs4755404, rs2269272, rs6296 and rs1659400), which showed evidence of association with SA compared to a non-attempter control group. We provide evidence of a 3-locus gene-gene interaction, and a putative gene-environment interaction, whereby genetic variation at the NTRK2 locus may moderate the risk associated with history of childhood abuse. CONCLUSION: Preliminary findings suggest that allelic variability in SLC1A2/3, 5-HTR1B and NTRK2 may be relevant to the underlying diathesis for suicidal acts.
    Language
    eng
    ISSN
    1744-9081 (Electronic)
    1744-9081 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1186/1744-9081-7-22
    Scopus Count
    Collections
    St. Vincent's University Hospital

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