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    Obstructive sleep apnea and inflammation.

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    Authors
    McNicholas, Walter T
    Affiliation
    Sleep Research Laboratory, St. Vincent's University Hospital, Dublin, Ireland., walter.mcnicholas@ucd.ie
    Issue Date
    2012-02-01T10:28:26Z
    MeSH
    Animals
    Anoxia/immunology
    Biological Markers/metabolism
    C-Reactive Protein/metabolism
    Cardiovascular Diseases/*immunology
    Cell Adhesion Molecules/metabolism
    Humans
    Inflammation/*immunology
    Inflammation Mediators/*metabolism
    Interleukins/metabolism
    Obesity/immunology
    Oxidative Stress
    Risk Factors
    Sleep Apnea, Obstructive/complications/*immunology
    Tumor Necrosis Factor-alpha/metabolism
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    Citation
    Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):392-9.
    Journal
    Progress in cardiovascular diseases
    URI
    http://hdl.handle.net/10147/207021
    DOI
    10.1016/j.pcad.2008.10.005
    PubMed ID
    19249445
    Abstract
    The pathogenesis of cardiovascular complications in obstructive sleep apnea syndrome (OSAS) is not fully understood but is likely multifactorial in origin. Inflammatory processes play an important role in the pathogenesis of atherosclerosis, and circulating levels of several markers of inflammation have been associated with future cardiovascular risk. These include cell adhesion molecules such as intercellular adhesion molecule-1 and selectins, cytokines such as tumour necrosis factor alpha and interleukin 6, chemokines such as interleukin 8, and C-reactive protein. There is also increasing evidence that inflammatory processes play an important role in the cardiovascular pathophysiology of OSAS and many of the inflammatory markers associated with cardiovascular risk have been reported as elevated in patients with OSAS. Furthermore, animal and cell culture studies have demonstrated preferential activation of inflammatory pathways by intermittent hypoxia, which is an integral feature of OSAS. The precise role of inflammation in the development of cardiovascular disease in OSAS requires further study, particularly the relationship with oxidative stress, metabolic dysfunction, and obesity.
    Language
    eng
    ISSN
    1532-8643 (Electronic)
    0033-0620 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.pcad.2008.10.005
    Scopus Count
    Collections
    St. Vincent's University Hospital

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